Publications and Abstracts

Publications and Abstracts

Scientific studies made possible by Glaucoma Research Foundation are changing the way doctors treat glaucoma — and speeding the search for a cure. Sharing these studies across the bioscience community ensures that today’s discoveries inspire and inform future research.

How Do We Share Discoveries?
Drs. Monica Vetter and Nick Marsh-Armstrong — members of the first pioneering Catalyst for a Cure consortium — explain how their collaborative findings influence others in the quest for glaucoma innovation.



Video Transcript

Monica Vetter, PhD: Citation is a very technical term, but it simply means that other scientists have read your work and they’ve thought about your work, and then they use that to inform what they’re going to do. And if they cite it, if they reference your work in their published papers, it means that they feel that the paper that they’re citing was an important concept that guided their subsequent experiments. And so as Dr. Horner said, it’s a barometer of what kind of influence the work is having in the field. Does it actually lead people to have new insights that then launches them in new directions and helps drive the field forward?

Nicholas Marsh-Armstrong, PhD: Having our work cited so often is evidence to us that we’re having a big impact, and I think that we know that already. So I think having our work cited so often by other scientists, many of whom we respect to a high degree, is just evidence to us that we’re having a big impact in driving the future of glaucoma research. I think that the Glaucoma Research Foundation’s vision in making this collaborative effort that we call “The Catalyst For a Cure” will have a long lasting impact on how glaucoma is studied in the future and how it will be treated in the future. So I think it was money well invested.

End of transcript.
“Having our work cited so often by other scientists, many of whom we respect to a high degree, is just evidence to us that we’re having a big impact in driving the future of glaucoma research.”
Nicholas Marsh-Armstrong, PhDCatalyst for a Cure investigator (CFC1)

How do the results of glaucoma research conducted in the laboratory make their way into the world? Scientists publish their findings, making them accessible to other researchers, who build on them in their own work.

This exchange of knowledge starts with peer review, a scholarly process used in the publication of scientific research manuscripts. Peer review ensures high quality standards by subjecting an author’s work or ideas to the scrutiny of experts in the field. Each reviewer returns an evaluation of the manuscript, including suggestions for improvement, to an editor or other intermediary. Once research is refined and published, other scientists who take inspiration from the work will reference the study with a citation in their scientific report.

Studies supported by Glaucoma Research Foundation have been influential in and beyond the field of ophthalmology. Findings from our first Catalyst for a Cure initiative — the endeavor that redefined glaucoma as a neurological disorder, not just a disease of the eye — have been cited by other scientists more than 8,000 times. Each citation is a vote of confidence that our community’s investments in collaborative research are advancing the quest for a glaucoma cure and shaping the future of health care overall.

Publications and Abstracts



Shaffer Research Grants

Following are selected peer-reviewed publications resulting from research made possible by grants from the Glaucoma Research Foundation.

To view the abstract of an article, copy the article name and paste it into the search box at the PubMed web site, www.pubmed.gov (a service of the National Library of Medicine and the National Institutes of Health).

Derek S. Welsbie, MD, PhD: Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proceedings of the National Academy of Sciences, March 15, 2013, Vol. 35, pp. 56-65. European Journal of Neuroscience 2012, Vol. 110 no. 10, 4045-4050

William Baldridge, PhD: Functional evidence for D-serine inhibition of non-N-methyl-D-aspartate ionotropic glutamate receptors in retinal neurons. European Journal of Neuroscience 2012, Vol. 35, pp. 56-65

Janice Vranka, PhD: Segmental versican expression in the trabecular meshwork and involvement in outflow facility. Investigative Ophthalmology & Visual Science 2011; 52(8)

An Zhou, PhD: Retinal proteomic changes under different ischemic conditions – implication of an epigenetic regulatory mechanism. International Journal of Physiology, Pathophysiology and Pharmacology 2010; 2(2): 148-160

Deborah C. Otteson, PhD: A role for DNA methylation in regulation of EphA5 receptor expression in the mouse retina. Vision Research 2010, September 25

Raquel L. Lieberman, PhD: Rescue of Glaucoma-Causing Mutant Myocilin Thermal Stability by Chemical Chaperones. ACS Chemical Biology 2010, March 24

Kate E. Keller, PhD: Differential Effects of ADAMTS-1, -4, and -5 in the Trabecular Meshwork. Investigative Ophthalmology & Visual Science 2009; 50 (12)

Kate E. Keller, PhD: Extracellular matrix turnover and outflow resistance. Experimental Eye Research 2009; 88

Yutao Liu, MD: Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma. Molecular Vision 2008; 14

Brad Fortune, PhD: Relative course of retinal nerve fiber layer birefringence and thickness and retinal function changes after optic nerve transection. Investigative Ophthalmology & Visual Science 2008; 49:10

Keith Martin, MD: Development and characterization of an adult retinal explant organotypic tissue culture system as an in vitro intraocular stem cell transplantation model. Investigative Ophthalmology & Visual Science 2008; 49:8

Ruth Ashery-Padan, PhD: Dual requirement for Pax6 in retinal progenitor cells. Development 2008 135: 24

Jonathan Crowston, MD: Oxidative Stress Is an Early Event in Hydrostatic Pressure-Induced Retinal Ganglion Cell Damage. Investigative Ophthalmology & Visual Science 2007; 48:10

Sayoko E. Moroi, MD: Evaluation of the ß2-Adrenergic Receptor Gene as a Candidate Glaucoma Gene in 2 Ancestral Populations. Archives of Ophthalmology 2007 Jan;125:1.

Lin Wang, MD: Microspheres method for ocular blood flow measurement in rats: size and dose optimization. Experimental Eye Research 2007 84:1

Mark Filla, PhD: ß1 and ß3 Integrins Cooperate to Induce Syndecan-4 Containing Cross-Linked Actin Networks in Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 2006; 47:5

Michèle Sale, PhD: Confirmation of the Adult-Onset Primary Open Angle Glaucoma Locus GLC1B at 2cen-q13 in an Australian Family. Ophthalmologica 2006; 220:23-30

Philip Gage, PhD: Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye. Investigative Ophthalmology & Visual Science 2005; 46:11

Ernst Tamm, MD: Ectopic Norrin Induces Growth of Ocular Capillaries and Restores Normal Retinal Angiogenesis in Norrie Disease Mutant Mice. The Journal of Neuroscience 2005; 25:7

Michèle Sale, PhD: Linkage to 10q22 for Maximum Intraocular Pressure and 1p32 for Maximum Cup-to-Disx Ration in an Extended Primary Open-Angle Glaucoma Pedigree. Investigative Ophthalmology & Visual Science 2005; 46:10

Brad Fortune, OD, PhD: The Gradient of Retinal Functional Changes During Acute Intraocular Pressure Elevation. Investigative Ophthalmology & Visual Science 2005; 46:1

Joseph Caprioli, MD: Calpain and N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat retinas. Brain Research 2005; 1046(1-2):207-15
Luca Scorrano, MD, PhD: OPA1 Requires Mitofusin 1 to Promote Mitochondrial Fusion. PNAS 2004; 101:45

Michal Schwartz, PhD: Antigenic Specificity of Immunoprotective Therapeutic Vaccination for Glaucoma. Investigative Ophthalmology & Visual Science 2003; 44:8

Joseph Caprioli, MD: Hyperthermic pre-conditioning protects retinal neurons from N-methyl-D-aspartate (NDMA)-induced apoptosis in rat. Brain Research 2003;

Joseph Caprioli, MD: 2-Deoxy-D-glucose protects retinal ganglion cells against excititoxicity. NeuroReport; Vol 14 No 18 19 Dec 2003

Gülgün Tezel, MD: Immunohistochemical Assessment of the Glial Mitogen-Activated Protein Kinase Activation in Glaucoma. Investigative Ophthalmology & Visual Science 2003; 44:7

Edward Essock, PhD: Fourier Analysis of optical coherence Tomography and scanning laser polarimetry retinal nerve fiber layer measurements in the diagnosis of glaucoma. Archives of Ophthalmology 2003; 121:9

Ted S. Acott, PhD: Involvement of the Erk-MAP Kinase Pathway in TNFa Regulation of Trabecular Matrix Metalloproteinases and TIMPs. Investigative Ophthalmology & Visual Science 2003; 44:1

Ted S. Acott, PhD: Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch. Investigative Ophthalmology & Visual Science 2003; 44:12

Larry Benowitz, PhD: Macrophage-Derived Factors Stimulate Optic Nerve Regeneration. Journal of Neuroscience 2003; 23 (6): 2284-2293

Joseph Caprioli, MD: Retinal Ganglion Cell Protection with Geranylgeranylacetone, A Heat Shock Protein Inducer, in a Rat Glaucoma Model. Investigative Ophthalmology & Visual Science 2003; 44:5

Andrew Iwach, MD (GREG): Long-Term Results of Noncontact Transcleral Neodymium:YAG Laser Cyclophotocoagulation for Neovascular Glaucoma. Ophthalmology. 2003; 110(5):895-9.

Andrew Iwach, MD (GREG): Transconjunctival Mitomycin-C in Needle Revisions of Failed Filtering Blebs. Ophthalmology. 2003; 110(4):734-42.

Andrew Iwach, MD (GREG): Comparison of the Efficacy of the Fixed-Combination Timolol/Dorzolamide Versus Concomitant Administration of Timolol and Dorzolamide. Journal of Ocular Pharmacology and Therapeutics 2003; 19(2):93-6.

Michal Schwartz, PhD: Resistance of Retinal Ganglion Cells to an Increase in Intraocular Pressure is Immune-Dependent. Investigative Ophthalmology & Visual Science 2002; 43:8

Philip Gage, PhD: Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development. 2002; 129: 329

Henry Jampel, MD: Correlation of the Binocular Visual Field with Patient Assessment of Vision. Investigative Ophthalmology & Visual Science 2002; 43:4

Darryl Nishimura, PhD: Genetic Analysis of PITX2 and FOXC1 in Rieger Syndrome in Patients From Brazil. Journal of Glaucoma 2002; 11:51

Cassandra Schlamp, PhD: p53 regulated apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate. Molecular Vision 2002; 8:341-350

Haiyan Gong, MD, PhD: The Mechanism of Increasing Outflow Facility during Washout in the Bovine Eye. Investigative Ophthalmology & Visual Science 2002; 43:11

Stanislav I. Tomarev, PhD: Optimedin: A Novel olfactomedin-related protein that interacts with myocilin. Human Molecular Genetics 2002; 11:11

Christopher Bowd, PhD: Comparing Neural Networks and Linear Discriminant Functions for Glaucoma Detection using Confocal Scanning Laser Ophthalmoscopy of the Optic Disc. Investigative Ophthalmology & Visual Science 2002; 43:11

Andrew Iwach (GREG): Long-Term Follow-Up of Initially Successful Trabeculectomy with 5-Fluorouracil Injections. Ophthalmology 2002;109(10):1921-4.

Andrew Iwach, MD (GREG): Filtering Bleb Modification with a THC:YAG (Holmium) Laser. Ophthalmic Surgery and Lasers 2002 May-Jun;33(3):181-7.

Michal Schwartz, PhD: Self-Protecting Mechanism awakened by Glutamate in Retinal Ganglion Cells. Journal of Neurotrauma 2001; Vol. 18:339

Darryl Nishimura, PhD: A Spectrum of FOXC1 Mutations Suggests Gene Dosage as a Mechanism for Developmental Defects of the Anterior Chamber of the Eye. American Journal of Human Genetics 2001; 68:364

Cassandra Schlamp, PhD: Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Molecular Vision 2001; 7:192-201

Terete Borras, PhD: Inefficient Processing of an Olfactomedin-Deficient Myocilin Mutant: Potential Physiological Relevance to Glaucoma. Biochemical and Biophysical Research Communications 2001; 282 662-670

Gülgün Tezel, MD: Serum Autoantibodies to Heat Shock Proteins in Glaucoma Patients from Japan and the US. Ophthalmology 2001; 108:296-302

Gülgün Tezel, MD: Induction of HLA-DR Expression in Human Lamina Cribrosa Astrocytes by Cytokines and Simulated Ischemia. Investigative Ophthalmology & Visual Science 2001; 42:2

Gülgün Tezel, MD: In Vitro Evaluation of Reactive Astrocyte Migration, A Component of Tissue Remodeling in Glaucomatous Optic Nerve Head. GLIA 2001; 34:178-189

Gülgün Tezel, MD: Serum Autoantibody against Glutathione S-Transferase in Patients with Glaucoma. Investigative Ophthalmology & Visual Science 2001; 42:6

Gülgün Tezel, MD: Clinical Factors Associated with Progression of Glaucomatous Optic Disc Damage in Treated Patients. Archives of Ophthalmology 2001; Vol. 119

Gülgün Tezel, MD: TNF- and TNF- Receptor-1 in the Retina of Normal and Glaucomatous Eyes. Investigative Ophthalmology & Visual Science 2001; 42:8

Joseph Caprioli, MD: Induction of Heat Shock Protein 72 in Retinal Ganglion Cells of a Rat Glaucoma Model. Investigative Ophthalmology & Visual Science 2001; 42:0

Michal Schwartz, PhD: Vaccination for Neuroprotection in the Mouse Optic Nerve: Implications for Optic Neuropathies. Journal of Neuroscience 2001; Vol. 21(1) 136-42

Michal Schwartz, PhD: Vaccination for Protection of Retinal Ganglion Cells Against Death from Glutamate Cytotoxicity and Ocular Hypertension: Implications for Glaucoma. Proc. National Academy of Sciences USA 2001; 98:6

Donald Zack, MD: Obstructed Axonal Transport of BDNF and its Receptor TrkB in Experimental Glaucoma. Investigative Ophthalmology & Visual Science 2000; 41:3

Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: GLC1F, A New Primary Open-angle Glaucoma Locus, Maps to 7q35-q36. Archives of Ophthalmology 1999; Vol. 117

Jorge Alvarado, MD; Johnnie Underwood, PhD: Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. AJP-Cell Physiology 1999; Vol. 277:2

James Brandt, MD; Martha O’Donnell, PhD: How Does the Trabecular Meshwork Regulate Outflow? Clues From the Vascular Endothelium. Journal of Glaucoma 1999; 8:328-339

James Brandt, MD; Martha O’Donnell, PhD: Effects of Na-K-2Cl Cotransport Regulators on Outflow Facility in Calf and Human Eyes in Vitro. Investigative Ophthalmology & Visual Science 1999; 40:8

James Brandt, MD; Martha O’Donnell, PhD: Na-K-2Cl Cotransport in Normal and Glaucomatous Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 1999; 40:2

Paul Kaufman, MD:_ H-7 Increases Trabecular Facility and Facility after Ciliary Muscle Disintertion._ Investigative Ophthalmology & Visual Science 1999, 40:1

Paul Kaufman, MD: Latrunculin-A Causes Mydriasis and Cycloplegia in the Cynomolgus Monkey. Investigative Ophthalmology & Visual Science 1999; 40:3

Paul Kaufman, MD: Effect of Staurosporine on Outflow Facility in Monkeys. Investigative Ophthalmology & Visual Science 1999; 40:5

Paul Kaufman, MD: Latrunculin-A Increases Outflow Facility in the Monkey. Investigative Ophthalmology & Visual Science 1999; 40:5

Robert Wordinger, PhD: Expression of Alternatively Spliced Growth Factor Receptor Isoforms in the Human Trabecular Meshwork. Investigative Ophthalmology & Visual Science 1999; 40:1

Robert Wordinger, PhD: Fas-Activated Apoptosis and Apoptosis Mediators in Human Trabecular Meshwork Cells. Experimental Eye Research 1999; Vol. 68 583-590

Robert Wordinger, PhD: Effects of Glucocorticoids on the Trabecular Meshwork: Towards a Better Understanding of Glaucoma. Progression Retina & Eye Research 1999; Vol. 18:5

Robert Nickells, PhD: Experimental Induction of Retinal Ganglion Cell Death in Adult Mice. Investigative Ophthalmology & Visual Science 1999; 40:5

Martin Wax, MD: Effects of Methotrexate Treatment on Serum Immunoreactivity of a Patient with Normal-Pressure Glaucoma. American Journal of Ophthalmology June 1999

Martin Wax, MD: Serum Autoantibodies to Optic Nerve Head Glycosaminoglycans in Patients with Glaucoma. Archives of Ophthalmology 1999; V.117

Martin Wax, MD: The Effects of Fludrocortisone on Retrobulbar Hemdynamic Parameters in Normal Pressure Glaucoma Patients with Low Blood Pressure. Annals of Ophthalmology 1999; 31:3

Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Insulin-Like Growth Factor Binding Protein-5 Expression by Human Trabecular Meshwork. Investigative Ophthalmology & Visual Science 1998; 39:1

Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Prospects for Genetic Intervention in Primary Open-angle Glaucoma. Drugs & Aging 1998; 13:5

R. Rand Allingham, MD; Janey Wiggs, MD: Gln368STOP Myocilin Mutation in Families with Late -Onset Primary Open Angle Glaucoma. Investigative Ophthalmology & Visual Science 1998; 39:12

W. Lee Alward, MD: The Forkhead Transcription Factor Gene FKHL7 is responsible for Glaucoma Phenotypes which Map to 6p25. Nature Genetics 1998; 19: 140

W. Lee Alward, MD: Clinical Features Associated with Mutations in the Chromosome 1 Open-Angle Glaucoma Gene. New England Journal of Medicine 1998; 338:1022

Ted Acott, PhD: Growth Factor and Cytokine Modulation of Trabecular Meshwork Matrix Metalloproteinase and TIMP Expression. Current Eye Research, 1998; 17:276-285

Ted Acott, PhD: Insulin-Like Growth Factor Binding Protein-5 Expression by Human Trabecular Meshwork. Investigative Ophthalmology & Visual Science 1998; 39:1

Ted Acott, PhD: Effect of Matrix Metalloproteinases Activity on Outflow in Perfused Human Organ Culture. Investigative Ophthalmology & Visual Science 1998; 39:13

Jorge Alvarado, MD; Johnnie Underwood, PhD: Effect of b-Adrenergic Agonists on Paracellular Width and Fluid Flow across Outflow Pathway Cells. Investigative Ophthalmology & Visual Science 1998, 39:10

David Epstein, MD: Mechanical Stretch Alters the Actin Cytoskeletal Network and Signal Transduction in Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 1998; 39:8

Paul Kaufman, MD: H-7 Disrupts the Actin Cytoskeleton and Increases Outflow Activity. Archives of Ophthalmology 1998; Vol. 116

Paul Kaufman, MD: Effects of H-7 on the Iris and Ciliary Muscle in Monkeys. Archives of Ophthalmology 1998; Vol. 116

John Polansky, MD; Thai Nguyen, PhD: Gene Structure and Properties of an Olfactomedin-related Glycoprotein, TIGR, Cloned from Glucocorticoid-induced Trabecular Meshwork Cells. Journal of Biological Chemistry 1998

John Polansky, MD; Thai Nguyen, PhD: The TIGR Gene, Pathogenic mechanisms, and other recent advances in glaucoma genetics. Current Opinion in Ophthalmology 1998; 9(11) 15-23

Robert Wordinger, PhD: Cultured Human Trabecular Meshwork Cells Express Functional Growth Factor Receptors. Investigative Ophthalmology & Visual Science 1998; 39:9

Evan Dreyer, MD: A Proposed Role for Excitotoxicity in Glaucoma. Journal of Glaucoma 1998; 7:62-67

Evan Dreyer, MD: Nitrate Therapy may retard glaucomatous optic neropathy, perhaps through modulation of glutamate receptors. Vision Research 1998; 38:1489-1494

Martin Wax, MD: Anti-Ro/SS- A Positivity and Heat Shock Protein Antibodies in Patients with Normal -pressure glaucoma. American Journal of Ophthalmology 1998; 125:2

Martin Wax, MD: Clinical and Ocular Histopathological Findings in a Patient With Normal-Pressure Glaucoma. Archives Of Ophthalmology 1998; V.116

Martin Wax, MD: Autoantibodies to Small Heat Shock Proteins in Glaucoma. Investigative Ophthalmology & Visual Science 1998; 39:12

Andrew Iwach, MD (GREG): Endoscopic Diode Laser Cyclophotocoagulation via a Limbal Approach. Ophthalmic Surgery and Lasers 1997 Feb;28(2):118-23.

Andrew Iwach, MD (GREG): Clinical Experience of Trabeculotomy for the Surgical Treatment of Aniridic Glaucoma. Ophthalmology 1997 Dec;104(12):2121-5.

Martin Wax, MD: Vacuolar H+ -ATPase in ocular ciliary epithelium. Proc. National Academy of Sciences 1997; 94: 6752-6757

Martin Wax, MD: Parapapillary Chorioretinal Atrophy in Patients With Ocular Hypertension I. Archives Of Ophthalmology 1997; V.115

Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Manipulation of Matrix Metalloproteinase Activity Modulates Outflow in Perfused Human Organ Culture. Investigative Ophthalmology & Visual Science 1997

Douglas Anderson, MD: Reproducibility of Laser Doppler Flowmetry in the Human Optic Nerve Head. Journal of Glaucoma 1997; 6: 212-216

Evan Dreyer, MD: Amino Acid Abnormalities in the Vitreous of the Buphthalmic Rabbit. Veterinary & Comparative Ophthalmology 1997; 7:3

Evan Dreyer, MD: The Role of Neuronal and Endothelial Nitric Oxide Synthase in Retinal Excitotoxicity. Association for Research in Vision and Ophthalmology 1997; 38:10

Evan Dreyer, MD: Molecular Basis of Glutamate Toxicity in Retinal Ganglion Cells. Vision Research 1997; 37:24

M. Rosario Hernandez, DDS: Hyaluronic Acid in the Normal and Glaucomatous Optic Nerve. Experimental Eye Research 1997; 64: 587-595

M. Rosario Hernandez, DDS: Astrocyte Responses in Human Optic Nerve Head with Primary Open-Angle Glaucoma. Journal of Glaucoma 1997; 6: 103-313

James Brandt, MD; Martha O’Donnell, PhD: Effects of Dexamethasone On Na-K-Cl Cotransport in Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 1997; 38:6

David Epstein, MD: Signal Transduction in Human Trabecular Meshwork Cells. Ocular Cell and Molecular Biology January 1997

Douglas Johnson, MD; Paul Russell, PhD: Ultrastructural Changes in the Trabecular Meshwork of Human Eyes Treated with Corticosteroids. Archives of Ophthalmology March 1997; Vol. 115

John Polansky, MD; Thai Nguyen, PhD: Glaucoma Gene Provides Light at the End of the Tunnel. Science 1997; Vol. 275

John Polansky, MD; Thai Nguyen, PhD: Identification of a Gene That Causes Primary Open Angle Glaucoma. Science 1997; Vol 275 pp. 668-670

John Polansky, MD; Thai Nguyen, PhD: Cellular Pharmacology and Molecular Biology of the Trabecular Meshwork Inducible Glucocorticoid Reponse Gene Product. Ophthalmology 1997; 211: pp. 126-139

Douglas Johnson, MD; Paul Russell. PhD: Enzymes Protective of Oxidative Damage Present in all Decades of Life in The Trabecular Meshwork, as Detected by Two-Dimensional Gel Electrophoresis Protein Maps. Journal of Glaucoma 1996; 5: 317-324

Paul Kaufman, MD; Mark Johnson, PhD; Thomas Freddo, PhD: IOP and Outflow Facility are Unchanged Following Acute and Chronic Intracameral Chondroitinase ABC and Hyaluronidase in Monkeys. Investigative Ophthalmology & Visual Science 1996; 37:3

Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Proteoglycan expression by human trabecular meshworks. Current Eye Research December 19, 1996

Douglas Anderson, MD: Laser Doppler Flowmetry Measurement of Changes in Human Optic Nerve Head Blood Flow in Response to Blood Gas Peturbations. Journal of Glaucoma 1996; 5 (4): 258-265

Douglas Anderson, MD: Dynamic Response of Optic Nerve Head Blood Flow to Increased Intraocular Pressure. Investigative Ophthalmology & Visual Science 1996; 37:3

Evan Dreyer, MD: Elevated Glutamate Levels in the Vitreous Body of Humans. Archives of Ophthalmology 1996; V.114

Paul Kaufman, MD: Latrunculin LAT-A and Staurosporine, But not Swinholide (SWIN) -A, Increase Outflow Facility in the Monkey. Investigative Ophthalmology & Visual Science 1996; 37:3

Paul Kaufman, MD: The Protein kinase inhibitor H-7 increases outflow facility and inhibits miotic but not accommodative responses to pilocarpine in monkeys. Investigative Ophthalmology & Visual Science 1996; 37:3

Andrew Iwach, MD (GREG): Trabeculectomy with Intraoperative Sponge 5-Flourouracil. Ophthalmology 1996 Jun;103(6):963-70.

Andrew Iwach, MD (GREG): Update of the Subconjuctival THC:YAG (Holmium) Laser Sclerostomy Ab Externo Clinical Trail: 4-Year Report. Ophthalmic Surgery and Lasers 1996, 27:823.

Andrew Iwach, MD (GREG): A High Prevalence of Occludable Angles in a Vietnamese Population. Ophthalmology 1996, Vol. 103, No. 9.

Douglas Anderson, MD: Autoregulation of Human Optic Nerve Head Circulation in Response to Increased Intraocular Pressure. Investigative Ophthalmology & Visual Science 1995; 36(4)

Andrew Iwach, MD (GREG): Long-term Results of Noncontact Transscleral Neodymium:YAG Cyclophotocoagulation. Ophthalmology 1995, Vol. 102, No. 12.



Catalyst for a Cure 2

The Catalyst for a Cure Biomarker team of scientists (CFC 2) has received important peer acknowledgment in key science publications. The following list of publications and Abstracts represents research results published since 2012.

2012

M.B. Steketee, S.N. Moysidis, J.E. Weinstein, A. Kreymerman, J. Silva, S. Iqbal, J.L. Goldberg (2012). Mitochondrial dynamics regulate growth cone motility, guidance, and neurite growth rate in perinatal retinal ganglion cells in vitro. IOVS, 53(11):7402-11.

J.E. Weinstein, M.B. Steketee, J.L. Goldberg (2012). Developmental Distribution of Mitochondria in Retinal Ganglion Cell Axons. ARVO 3968/D832.

M. Steketee, J.E. Weinstein, A. Kreymerman, J.L. Goldberg (2012). Activity-dependent expression of nuclear encoded mitochondrial proteins in retinal ganglion cell axons in vivo. SFN 312.08.

A. Dubra and Y.N. Sulai, “First-order design of a reflective viewfinder for adaptive optics ophthalmoscopy,” Opt. Express 20, 26596-26605 (2012).

2013

A. Kreymerman, M. Steketee, Y. Wang, J.L. Goldberg (2013). The role of mitochondrial fission/fusion in CNS axon regeneration. SFN San Diego, CA: 126.12/A26.

V.J. Srinivasan, H. Radhakrishnan, “Total average blood flow and angiography in the rat retina,” J Biomed Opt. 18(7):076025, (2013).

H. Radhakrishnan, V.J. Srinivasan, “Multi-parametric OCT imaging of the inner retinal hemodynamic response to visual stimulation,” J Biomed Opt. 18(8):086010, (2013).

A. Pinhas, M. Dubow, N. Shah, T.Y. Chui, D. Scoles, Y. Sulai, R. Weitz, J.B. Walsh, J. Carroll, A. Dubra, R. B. Rosen, “In vivo imaging of human retinal microvasculature using adaptive optics scanning light ophthalmoscope fluorescein angiography,” Biomed. Opt. Express 4, 1305-1317 (2013).

2014

O.S. Dhande, A.D. Huberman (2014) Retinal ganglion cell maps in the brain: implications for visual processing. Current Opinion in Neurobiology 24(1):133-42.

A. Kreymerman, Y. Wang, N.J. Kunzevitzky, M.B. Steketee, J.L. Goldberg (2014). The role of mitochondrial fission/fusion in CNS axon regeneration. SFN, Washington DC, 399.11/C14

A. Kreymerman, J.L. Goldberg (2014). Role of mitochondrial dynamics in axon growth. Joint Symposium of the 4th International Neural Regeneration Symposium, 6th International Spinal Cord Injury Treatments and Trials Symposium, and the 9th Asia Pacific Symposium on Neural Regeneration, Nanjing, China

S. P. Chong, C. Merkle, H. Radhakrishnan, C. Leahy, A. Dubra, Y. Sulai, and V. J. Srinivasan, Optical Coherence Imaging of Microvascular Oxygenation and Hemodynamics, in CLEO: 2014, OSA Technical Digest (online) (Optical Society of America, 2014)

Y.N. Sulai, D. Scoles, Z. Harvey and A. Dubra, “Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope,” J. Opt. Soc. Am. A 31, 569-579 (2014). PMID: 24690655

Y.N. Sulai and A. Dubra, “Non-common path aberration correction in an adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 5, 3059-3073 (2014).

D.H. Scoles, B.P. Higgins, R.F. Cooper, A.M. Dubis, P. Summerfelt, D.V. Weinberg, J.E. Kim, K.E. Stepien, J. Carroll and A. Dubra, “Microscopic Inner Retinal Hyper-Reflective Phenotypes in Retinal and Neurologic Disease,” Invest. Ophthalmol. Vis. Sci.55 (7), 4015-29 (2014).

D.H. Scoles, Y.N. Sulai, C. Langlo, G.A. Fishman, C.A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55 (7), 4244-4251(2014).

T.Y. P. Chui, M. Dubow, A. Pinhas, N. Shah, A. Gan, R. Weitz, Y.N. Sulai, A. Dubra and R.B. Rosen, “Comparison of adaptive optics scanning light ophthalmoscopic fluorescein angiography and offset pinhole imaging,” Biomed. Opt. Express 5, 1173-1189 (2014).

M. Dubow, A. Pinhas, N. Shah, R. Cooper, A. Gan, R. Gentile, V. Hendrix, Y. Sulai, J. Carroll, T. Chui, J. Walsh, R. Rosen and A. Dubra, “Classification of Human Retinal Microaneurysms using Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography” Invest. Ophthalmol. Vis. Sci. 55:1299-1309, (2014).

A. Pinhas, M. Razeen, M. Dubow, A Gan, T.Y. Chui, N. Shah, M. Mehta, R.C. Gentile, R. Weitz, J. Walsh, Y.N. Sulai, J. Carroll, A. Dubra and R.B. Rosen, “Assessment of perfused foveal microvascular density and identification of nonperfused capillaries in healthy and vasculopathic eyes,” Invest. Ophthalmol. Vis. Sci., 55(12):8056-66 (2014).

2015

R. N. El-Danaf, and A.D. Huberman (2015) Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types. Journal of Neuroscience. 35 (6):2329-43.

C. Leahy, H. Radhakrishnan, G. Weiner, J.L. Goldberg, and V.J. Srinivasan (2015). Mapping the 3-D connectivity of the rat inner retinal vascular network using OCT angiography. IOVS, 56(10): 5785-93.

J.E. Weinstein, J.L. Goldberg, M. Steketee (2015). Developmental Distribution of Mitochondria in Retinal Ganglion Cell Axons. ARVO Annual Meeting, Denver, CO: 4953 – B0152
Y. Takihara, M. Inatani, K. Etoc, T. Inoue, A. Kreymerman, S. Miyake, S. Ueno, M. Nagaya, A. Nakanishi, K. Iwao, Y. Takamura, H. Sakamoto, K. Satoh, M. Kondo, T. Sakamoto, J.L. Goldberg, J. Nabekura, and H. Tanihara (2015). In vivo imaging of mitochondrial axonal transport in the diseased and aged mammalian CNS. PNAS, 112(33):10515-20. PMC4547257

A. Kreymerman, M.B. Steketee, J.L. Goldberg (2015). The role of mitochondrial dynamics in CNS axon regeneration. SFN Annual Meeting, Chicago, 568.21/A64
M.F. Chen, T.Y.P. Chui, P. Alhadeff, R.B. Rosen, R. Ritch, A. Dubra and D.C. Hood, “Adaptive optics imaging of healthy and abnormal regions of retinal nerve fiber bundles of patients with glaucoma, Invest. Ophthalmol. Vis. Sci., 56, 674-681 (2015).

S.P. Chong, C. Merkle, H. Radhakrishnan, C. Leahy, V.J. Srinivasan. “Quantitative mapping of microvascular chromophores using visible light spectroscopic Optical Coherence Tomography.” Biomedical Optics Express. 6(4), 1429-1450 (2015).

D.C. Hood, M.F. Chen, D. Lee, B. Epstein, P. Alhadeff, R.B. Rosen, R. Ritch, A. Dubra and T.Y. Chui, “Confocal adaptive optics imaging of peripapillary nerve fiber bundles: implications for glaucomatous damage seen on circumpapillary OCT scans,” Transl. Vis. Sci. Technol. 4(2) article 12 (2015).

D.C. Hood, B. Fortune, M.A. Mavrommatis, J. Reynaud, R. Ramachandran, R. Ritch, R.B. Rosen, H. Muhammad, A. Dubra, T.Y.P. Chui, “Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps,” Invest. Ophthalmol. Vis. Sci, 56(11), 6208-6216 (2015).

A. Pinhas, M. Dubow, N. Shah, E. Cheang, C.L. Liu, M. Razeen, A. Gan, R. Weitz, Y.N. Sulai, T.Y. Chui, A. Dubra and R.B. Rosen, “Fellow eye changes in patients with central retinal vein occlusion: assessment of perfused foveal microvascular density and identification of nonperfused capillaries,” Retina 35(10), 2028-2036 (2015).

2016

J.L. Goldberg (2016). Optic nerve restoration: Bench to bedside. 2016 China – ARVO Networking Forum, ARVO Annual Meeting, Seattle, WA.

D. Buickians, A. Kreymerman, J.L. Goldberg (2016). Application of GRIN lens for in vivo fluorescence microscopy of retinal ganglion cells. UCSF/BioEngineering Institute of California, 17th Annual UC Systemwide Bioengineering Symposium.

J.L. Goldberg (2016). Biomarkers for Glaucoma and Pathways to Neuroprotection. Joint Conference, Neuroprotection in the Visual System, Hospital Gemelli, Rome, Keynote Speaker.

D. Buickians, A. Kreymerman, E. Huynh, Y. Gong, H. Chen, J.L. Goldberg (2016). Application of gradient index lens for In vivo fluorescent microscopy of retinal ganglion cells. Society for Neuroscience Annual Meeting, San Diego, CA: 560.13

A. Kreymerman, J. Weinstein, D. Buickians, T. Tran, N. Sun, L. Bazik, M. Steketee, J.L. Goldberg (2016). Mitochondrial dynamics in retinal ganglion cell development and regeneration. Society for Neuroscience Annual Meeting, San Diego, CA: 118.10

S.H. Shah, L.M. Schiapparelli, S. Saturday, D. McClatchy, Y. Ma, J. Yates, III, H. Cline, J.L. Goldberg (2016). Quantifying changes in protein synthesis and transport in optic neuropathies. Society for Neuroscience Annual Meeting, San Diego, CA: 210.09

L.M. Schiapparelli, S. Shah, D. McClatchy, H. He, J. Li, Y. Ma, S. Saturday, J.L. Goldberg, J. Yates, III, H. Cline (2016). Novel strategies for detection and identification of the axonal “transportome” and pre-synaptome” in the rodent visual system. Society for Neuroscience Annual Meeting, San Diego, CA: 210.22

Srinivasan, V. J., & Dubra, A. (2016). Noninvasive imaging of the photoreceptor mosaic response to light stimulation. Proceedings of the National Academy of Sciences, 113(46), 12902-12903.

Merkle, C. W., Leahy, C., & Srinivasan, V.J. (2016). Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris. Biomedical Optics Express, 7(10), 4289-4312.

Shieh, E., Lee, R., Que, C., Srinivasan, V., Guo, R., DeLuna, R., & Chen, T. C. (2016). Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans. American Journal of Ophthalmology, 169, 168-178.

Lim J-H, Nguyen PL, Lien BV, Wang C, Zukor K, He Z, Huberman AD (2016) Neural activity promotes long distance, target-specific regeneration of adult retinal axons. Nature Neuroscience, 19: 1073-84. [featured article]

N. Sredar, M.M. Razeen, Y.N. Sulai, B.S. Sajdak and A. Dubra (2016) “Non-confocal split-detection adaptive optics scanning light ophthalmoscope with small pupil for vascular imaging,” ARVO Annual Meeting, Seattle, WA, USA.

J. Tam, J. Liu, A. Dubra and R.N. Fariss (2016) “Visualization of retinal pigment epithelial cells using adaptive optics enhanced indocyanine green imaging,” ARVO Annual Meeting, Seattle, WA, USA.

D. Lee, T.Y. Chui, R. Jarukasetphon, R. B. Rosen, R. Ritch, A. Dubra and D.C. Hood (2016) “Local glaucoma progression detected by adaptive optics-scanning light ophthalmoscopy,” ARVO Annual Meeting, Seattle, WA, USA.

D. Scoles, J.A. Flatter, R.F. Cooper, C.S. Langlo, S. Robison, M. Neitz, D.V. Weinberg, M.E. Pennesi, D.P. Han, A. Dubra and J. Carroll (2016) “Assessing photoreceptor structure associated with ellipsoid zone disruptions visualized with optical coherence tomography,” ,” Retina 36(1):91-103.

B. Sajdak, Y.N. Sulai, C.S. Langlo, G. Luna, S.K. Fisher, D.K. Merriman and A. Dubra (2016) “Noninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic,” Vis Neurosci.33:E003.

T.Y.P. Chui, A. Pinhas, A. Gan, M. Razeen, N. Shah, E. Cheang, C.L. Liu, A. Dubra and R.B. Rosen (2016) “Longitudinal imaging of microvascular remodelling in proliferative diabetic retinopathy using adaptive optics scanning light ophthalmoscopy,” Ophthal. Physil. Opt. 36 (3), 290-302.

J. Liu , A. Dubra, R. Fariss and Johnny Tam (2016) “In vivo imaging of human retinal pigment epithelial mosaic using adaptive optics enhanced indocyanine green ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 57(10):4376-4384.

2017

Chong, S. P., Bernucci, M., Radhakrishnan, H., & Srinivasan, V.J. (2017). Structural and functional human retinal imaging with a fiber-based visible light OCT ophthalmoscope. Biomedical Optics Express, 8(1), 323-337.

B. Laha, B.K. Stafford BK, A.D. Huberman “Regenerating optic pathways from the eye to the brain.” Science, 356: 1031-1034 (2017)

Zhu, J., Merkle, C.W., Bernucci, M.T., Chong, S.P., & Srinivasan, V.J. (2017) “Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?,” Applied Sciences, 7(687).

B.T. Nguyen, J.L. Goldberg (2017). Retinal Ganglion Cell Regeneration Strategies for Vision Loss in Glaucoma. View on Glaucoma 12(1):18-21

L.M. Schiapparelli, S.H. Shah, Y. Ma, J. Yates III, H.T. Cline, J.L. Goldberg (2017). Quantifying protein synthesis and axonal transport in the visual system and its response after optic nerve injury. Society for Neuroscience Annual Meeting, Washington, D.C.: 684.10

L.M. Schiapparelli, S. Shah, D. McClatchy, H. He, J. Li, Y. Ma, S. Saturday, J.L. Goldberg, J. Yates, III, H. Cline (2016). Novel strategies for detection and identification of the axonal “transportome” and pre-synaptome” in the rodent visual system. Society for Neuroscience Annual Meeting, San Diego, CA: 210.22

Goldberg JL “Optic Nerve Regeneration, Bench to Bedside”. Hawaiian Eye, January 2017.

Goldberg JL “Update on Biomarkers for Glaucoma”. Glaucoma360 New Horizons, San Francisco, Feb 2017.

Goldberg JL “Optic Nerve Regeneration, Bench to Clinic”. MEEI Military Vision Conference, Mar 2017.

Goldberg JL “The Future of Glaucoma Diagnosis and Treatment” NY Glaucoma Society, June 2017.

Goldberg JL “Stem Cells and Biomarkers for Glaucoma”. Fox Center Regeneration Meeting, Washington, DC, July 2017.

Srinivasan, V.J., Chong, S.P. and Bernucci, M.T., 2017. Spectroscopic imaging of the outer retina with visible light OCT. Investigative Ophthalmology & Visual Science, 58(8), pp.5444-5444.

Bernucci, M.T., Merkle, C. and Srinivasan, V.J., 2017. Using a contrast agent to explain vascular scattering patterns in OCT angiography. Investigative Ophthalmology & Visual Science, 58(8), pp.5434-5434.

Chong, S.P., Bernucci, M.T., Borycki, D., Radhakrishnan, H. and Srinivasan, V.J., 2017, April. Structural and functional human retinal imaging with a fiber-based visible light OCT ophthalmoscope (Conference Presentation). In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI (Vol. 10053, p. 100530H). International Society for Optics and Photonics.

A.E. Salmon, R.F. Cooper, C.S. Langlo, A. Baghaie, A. Dubra and J. Carroll, “An Automated Reference Frame Selection (ARFS) Algorithm for Cone Imaging with Adaptive Optics Scanning Light Ophthalmoscopy,” Translational Vision Science & Technology 6:9 doi:10.1167/tvst.6.2.9 (2017). PMCID: PMC5381332

D.C. Hood, D. Lee, R. Jarukasetphon, J. Nunez, M.A. Mavrommatis, R.B. Rosen, R. Ritch, A. Dubra, T.Y.P. Chui, “Progression of local glaucomatous damage near fixation as seen with adaptive optics imaging,” Translational Vision Science & Technology 6(4):6. doi: 10.1167/tvst.6.4.6. (2017). PMCID: PMC5508541

C. Bergeles, A. M. Dubis, B. Davidson, M. Kasilian, A. Kalitzeos, J. Carroll, A. Dubra, M. Michaelides, and S. Ourselin, “Unsupervised identification of cone photoreceptors in non-confocal adaptive optics scanning light ophthalmoscope images,” Biomed. Opt. Express 8, 3081-3094 (2017). PMCID: PMC5480451

J. Liu, H.W. Jung, A. Dubra and J. Tam, “Automated Photoreceptor Cell Identification on Non-Confocal Adaptive Optics Images Using Multi-Scale Circular Voting,” Invest. Ophthalmol. Vis. Sci. 58(11):4477-4489. PMID: 28873173

D. Cunefare, L. Fang, R.F. Cooper, A. Dubra, J. Carroll and S. Farsiu, “Open source software for automatic detection of cone photoreceptors in adaptive optics ophthalmoscopy using convolutional neural networks,” Sci. Rep. 7, article # 6620 (2017).

T.A. Seabrook, O.S. Dhande, N. Ishiko, V.P. Wooley, P.L. Nguyen, A.D. Huberman, “Strict independence of parallel and poly-synaptic axon-target matching during visual reflex circuit assembly.” Cell Reports, 21: 3049- 3064. (2017)

2018

Merkle, C.W., Chong, S. P., Kho, A. M., Zhu, J., Dubra, A., & Srinivasan, V.J. (2018) “Visible light optical coherence microscopy of the brain with isotropic femtoliter resolution in vivo,” Optics Letters, 43(2).

Zhang, T., Chong, S. P., Kho, A. M., Dubra, A., & Srinivasan, V.J. (2018) “Ultrahigh resolution retinal imaging by visible light OCT with longitudinal achromatization”, Biomedical Optics Express, Vol. 9, Issue 4, pp. 1477-1491 (2018).

Bernucci, M.T., Merkle, C.W., & Srinivasan, V.J. (2018) “Investigation of artifacts in retinal and choroidal OCT angiography with a contrast agent,” Biomedical Optics Express, Vol. 9, Issue 3, pp. 1020-1040 (2018).



Catalyst for a Cure 1

The initial team of Catalyst for a Cure research scientists achieved important peer acknowledgment in key science publications. The following list of publications and abstracts represents research results published since 2005.

Papers and Manuscripts

Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons.
Lambert WS, Ruiz L, Crish SD, Wheeler LA, Calkins DJ.
Mol Neurodegener. 2011 Jan 13;6(1):4.

Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms.
Crish SD, Calkins DJ.
Neuroscience. 2011 Mar 10;176:1-11. Epub 2010 Dec 25. Review.

Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse.
Chen H, Wei X, Cho KS, Chen G, Sappington R, Calkins DJ, Chen DF.
Invest Ophthalmol Vis Sci. 2011 Jan 5;52(1):36-44.

Early microglia activation in a mouse model of chronic glaucoma.
Bosco A, Steele MR, Vetter ML.
J Comp Neurol. 2011 Mar 1;519(4):599-620.

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.
Nguyen JV, Soto I, Kim KY, Bushong EA, Oglesby E, Valiente-Soriano FJ, Yang Z, Davis CH, Bedont JL, Son JL, Wei JO, Buchman VL, Zack DJ, Vidal-Sanz M, Ellisman MH, Marsh-Armstrong N.
Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1176-81.

Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.
Soto I, Pease ME, Son JL, Shi X, Quigley HA, Marsh-Armstrong N.
Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):434-41.

Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss.
Son JL, Soto I, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, Marsh-Armstrong N.
Glia. 2010 May;58(7):780-9.

The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
Sappington, RM., Carlson, BJ., Crish, SD. & Calkins, D.J. (2010)
Investigative Ophthalmology & Visual Science, 51:207-16.

Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration
Baltan, S., Inman DM., Danilov, CA., Morrison, RS., Horner, PJ. & Calkins, D.J. (2010) Journal of Neuroscience, 30:5644-5652.

Distal axonopathy with structural persistence in glaucomatous neurodegeneration
Crish, SD., Sappington, R.M., Inman DM., Horner, PJ. & Calkins, D.J. (2010) Proceedings of the National Academy of Sciences of the US.107(11):5196-201.

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+ with Exposure to Hydrostatic Pressure
Sappington, R.M., Sidorova, T., Long, D.J. & Calkins, D.J. (2009)
Investigative Ophthalmology & Visual Science, 50:717-28.

Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma
Buckingham, B.P., Inman, D.M., Lambert, W., Oglesby, E., Calkins, D.J., Steele, M.R., Vetter, M.L., Marsh-Armstrong, N. & Horner, P.J. (2008)
Journal of Neuroscience, 28:2735-2744.

Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure
Sappington, R.M. & Calkins, D.J. (2008)
Investigative Ophthalmology & Visual Science, 49:3004-17.

Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma
Calkins, D.J., Horner, P.J., Roberts, R., Gradianu, M. & Berkowitz, B.A. (2008) Investigative Ophthalmology & Visual Science, 49:5083-5088.

Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T cell-derived Fas-ligand
Wax, M.B., Tezel, G., Yang, J., Peng, G., Patil, R.V., Agarwal, N., Sappington, R.M. & Calkins, D.J. (2008)
Journal of Neuroscience, 28:12085-12096.

A neurological perspective of glaucoma.
Calkins, D.J. (2008)
Glaucoma Today, September/October, pp. 18-20.

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
Soto, I., Oglesby, E., Buckingham, B.P., Son, J.L., Roberson, E.D., Steele, M.R., Inman, D.M., Vetter, M.L., Horner, P.J.& Marsh-Armstrong, N. (2008)
Journal of Neuroscience, 28:548-61.

Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma
Bosco A., Inman, D.M., Steele, M.R., Wu, G., Soto, I., Marsh-Armstrong, N., Hubbard, W.C., Calkins, D.J., Horner, P.J.& Vetter, M.L. (2008)
Investigative Ophthalmology & Visual Science, 49:1437-46.

Quantitative Correlation of Optic Nerve Pathology with Ocular Pressure and Corneal Thickness in the DBA/2 Mouse Model of Glaucoma
Inman DM., Sappington, RM., Horner, PJ. & Calkins, DJ., (2006)
Investigative Ophthalmology & Visual Science, 47:986-996.

Pressure-Induced Regulation of IL-6 in Retinal Glial Cells: Involvement of the Ubiquitin/Proteasome Pathway and NF_B Sappington, RM. & Calkins, DJ. (2006)
Investigative Ophthalmology & Visual Science, 47:3860-3869.

Interleukin-6 Protects Retinal Ganglion Cells from Pressure-Induced Death
Sappington, RM., Chan M. & Calkins, DJ. (2006)
Investigative Ophthalmology & Visual Science, 47:2932-2942.

Microarray Analysis of Retinal Gene Expression in the DBA/2J Model of Glaucoma
Steele, MR., Inman DM., Calkins, D.J., Horner, P.J. & Vetter, M.L. (2006)
Investigative Ophthalmology & Visual Science, 47:977-985.

Abstracts

Marsh-Armstrong, N., Soto, I., Oglesby, E., Davis, C.-HO., Mules, EH., Valiente-Soriano, F., Vidal-Sanz, M., Buchman, V., Watkins, PA., Nguyen, JV., (2010) Gamma-Synuclein Aggregation and Activation of Optic Nerve Head Astrocytes (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2100).

Breen, KT., Bosco, A., Fu, CT., Sretavan, DW, Vetter, ML (2010) Retinal Microglia Activate in a Mouse Model of Acute Ocular Hypertension (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2097).

Inman, DM., Knox, JM., Morrison, RS., Horner, PJ. (2010) DBA/2J Mitochondria Morphology and Distribution Varies With Age and Increasing IOP (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2140).

MacNamee, SE., Crish, SD., Juliao, SF., Lambert, WS., Calkins DJ. (2010) BDNF and TrkB Expression in the Retina of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2123).

Ho, KW., Juliao, SF., Zhao, B., Sappington, RM., Calkins DJ. (2010) Expression of the TRPV Family in the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2125).

Zhao, B., Crish, SD., Calkins DJ. (2010) Dendritic Morphology Changes Prior to Uptake and Transport Dysfunction in Retinal Ganglion Cells of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2141).

Crish, SD., MacNamee, SE., Calkins DJ. (2010) Target Response to Axonal Transport Loss in Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2142).

Dapper, JD., Crish, SD., Calkins DJ. (2010) Gene Expression Changes in Response to Age in the Superior Colliculus of the DBA/2J Mouse (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2154).

Shih, GC., Sternberg, MG., Crish, SD., Harth, EM., Calkins DJ. (2010) Nanoparticle Drug Delivery to Retinal Ganglion Cells in Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3167).

Sidorova, TN., Sappington, RM., Crish, SD., Lambert, WS., Calkins DJ. (2010) Cell Specific Localization of BDNF mRNA in the Mouse Visual Pathway Using Fluorescent in situ Hybridization (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3173).

Lupien, C., Calkins DJ., Horner PJ. (2010) Decreasing Gliosis by Inhibition of the Stat3 Pathway in a Microbead Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 3192).

Son, JL., Soto, I., Oglesby, E., Pease, ME., Quigley, HA., Marsh-Armstrong, N. (2009) Monitoring Glaucoma Progression in the Translimbal Trabecular Laser Photocoagulation Rat Model Using Molecular Markers (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2764).

Bosco, A., Steele, MR., Luo, L., Ambati, BK., Vetter, ML. (2009) Characterization of GFP-expressing Microglia in DBA/2J-Cx3cr1 +/GFP Retina (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2771).

Bosco, A., Steele, MR., Inman DM., Horner, PJ., Vetter, ML. (2009) Potential Role of Retinal Microglia in RGC Synapse Removal in DBA/2J Mice (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2770).

Calkins DJ., Inman, P., Horner PJ., Crish, S. (2009) Progression of Deficits in Anterograde Active Axonal Transport in the Retina of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 4317).

MacNamee, SE., Petty, B., Crish, SD., Calkins DJ.. (2009) Neurochemistry of RGC Axonal Dystrophies in the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2767).

Inman, DM., Baltan, S., Calkins DJ., Horner PJ. (2009) High IOP Decreases Compound Action Potential Amplitude and Leads to Preferential Loss of Physiologically Identified Small Caliber Axons in DBA/2 Optic Nerve (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2769).

Crish SD., Raymond, ID., Brecha, NC., Calkins DJ. (2009) Structural Persistence of the Retinal Ganglion Cell Projection in the DBA/2J Mouse Model of Pigmentary Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2777).

Lupien, D., Inman, DM., Calkins DJ., Horner PJ. (2009) Tempering Gliosis by Inhibition of the NFkB Pathway in an Acute Model of Glaucoma (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 2781).

Armstrong, BK., Sappington-Calkins, RM., Calkins DJ., Russ, PK., Chang, MS. (2009) Antibodies Specific to the Extracellular Domain of Bves Lowers IOP (Investigative Ophthalmology & Visual Science, 50: ARVO E-Abstract 4057).

Calkins DJ, Roberts R, M. Gradianu, Berkowitz BA. (2008) Manganese-Enhanced MRI studies of intraretinal ionic activity in the DBA/2J mouse model of glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 2878).

Wu G, Horner PJ, Calkins DJ. (2008) Age-dependent changes in morphologically identified glial cell populations in the optic nerve of the DBA/2J mouse model of pigmentary glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3693).

Crish SD, Balaram P, Inman DM, Horner PJ, Calkins DJ. (2008) Early transport deficits and distal axonopathy in the DBA/2J mouse model of pigmentary glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3664).

Balaram P, Crish SD, Calkins DJ. (2008) Upregulation of brain derived neurotrophic factor is related to transport loss in the superior colliculus of the DBA/2J mouse (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 4061).

Sappington RM, Sidorova TN, Calkins DJ. (2008) Trpv1 contributes to pressure-induced death and disruption of axonal transport in RGCs (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5481).

Bosco A, Steele MR, Vetter ML. (2008) Microglia Cell Activation and Clustering Herald the Onset of Glaucoma in DBA/2J Retina. (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5492).

Lambert W, Knox J, Steele MR, Bosco A, Wu G, Inman DM, Vetter ML, Calkins DJ, Horner PJ. (2008) Dietary Lipoic Acid Attenuates Oxidative Stress and Retinal Ganglion Cell Loss in the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5498).

Inman DM, Horner PJ. (2008) Neurotrophin Receptor Expression in Retinal and Optic Nerve Microglia Changes With Glaucoma and Age in the DBA/2J Mouse Model (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3703).

Lupien C, Inman DM, Horner PJ. (2008) Regulation of Gliosis in the DBA/2J Mouse Model of Glaucoma by NF-kB and STAT3 Pathways (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5489).

Marsh-Armstrong N, Cox E, Soto I. (2008) Gamma synuclein changes cellular distribution in glaucomatous DBA/2J mice (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5490).

Soto,I., Son,J., Marsh-Armstrong, N (2008) Proliferation and Oligodendrocyte Turnover in Optic Nerves of Glaucomatous DBA/2J Mice. (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 3687).

Soto, Son, Lopez-Roca, Oglesby & Marsh-Armstrong. Glial changes in the optic nerve correlate with axonal degeneration in a mouse glaucoma model. Molecular and Cellular Mechanisms of Axonal Degeneration Workshop. October 2008 Woods Hole, MA.

Bosco A, Steele MR, Vetter ML. Pathogenic Role Of Microglia In Early Stages Of Glaucoma. 2008 Cold Spring Harbor Laboratory Meeting on Glia in Health & Disease.

Gradianu, MD., Roberts, R., Inman, D., Horner, PJ., Calkins, DJ., Berkowitz, BA. (2007) Manganese-Enhanced MRI Studies of the DBA/2J Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 1974).

Sappington, RM., Calkins, DJ.(2007) Shrinkage and Loss of RGC Axons in a New Latex Bead Rat Model of High-Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 2878).

Crish, SD., Sappington, RM., Calkins, DJ.(2007) Axon Degeneration and Loss of Transport in a New Latex Bead Model of High-Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4352).

Long, DJ., Sappington, RM., Calkins, DJ.(2007) Pressure-induced Retraction of RGC Axons in an ex vivo Preparation of Rat Retina (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4356).

Sappington, RM., Calkins, DJ.(2007) Elevated Pressure Induces TRPV1-Mediated Ca2+-Dependent Apoptosis of Retinal Ganglion Cells (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4357).

Koh, JY., Sappington, RM., Calkins, DJ.(2007) Effects of TRPV1 Overexpression and Silencing on Retinal Ganglion Cell Survival in vitro (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4358).

Joos, KM., Jones, A., Li, C., Calkins, DJ.(2007) Effect of Intermittent IOP Elevation Over 12 Weeks in the Rat Retinal Neurochemical Signature (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3280).

Armstrong, BK., Sappington, RM., Sidorova, T.,Calkins, DJ.(2007) Activation of Glial Cells in a Latex Bead Rat Model of High Pressure Glaucoma (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3282).

Inman, D., Bosco, A., Steele, MR., Wu, G., Calkins, DJ., Horner, PJ., Vetter, ML.(2007) Chronic Minocycline Treatment Decreases Microglial Activation and Improves Retrograde Axonal Transport in Retinal Ganglion Cells in DBA/2J Retina (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3291).

Wu, G., Horner, PJ., Calkins, DJ..(2007) Morphometric Comparison of Age- and IOP-Dependent Changes in the Proximal and Distal Optic Nerve of the DBA/2J Mouse (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3664).

Balaram, P., Calkins, DJ.(2007) Concentration-Dependent Protection of Retinal Ganglion Cells From Pressure-Induced Apoptosis by Pre-Treatment With a Flavonol Flavonoid (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4944).

Marsh-Armstrong, N., Oglesby, E., Buckingham, B., Horner, PJ., Soto, I. (2007) Molecular Changes in DBA/2J Retinal Ganglion Cells Coinciding With Axonal Transport Dysfunction (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 5553).

Lupien, C., Horner, PJ.(2007) Stat3 Pathway in Glaucoma. A Study of the DBA/2J Mouse Model (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 5902).

Calkins, DJ., Koh, JY., Sappington, RM. (2006) TRPV1 Channels Modulate Pressure-Induced Death of Retinal Ganglion Cells (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1557).

Armstrong, BK., Kehler, LA., Sappington, RM., Calkins, DJ.(2006) Müller Cell Activation Correlates with Photoreceptor Loss in DBA/2 Mice (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1562).

Wax, MB., Tezel, G., Yang, J., Patil, R., Sappington, RM., Calkins, DJ.(2006) Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cells via a FAS/FAS-Ligand Pathway (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1828).

Wu, G., Inman, D., Horner, PJ., Calkins, DJ. (2006) Selective Loss of Large-Caliber Axons in the Optic Nerve of the DBA/2J Mouse With Modest Increases in Intraocular Pressure (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1829).

Koh, JY., Kammer, JA., Carlson, G., Wu, G., Calkins, DJ. (2006) Expression and Localization of FasL and CD95 in the DBA/2 Retina (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 5545).

Buckingham, BP., Inman, D., Calkins, DJ., Horner, PJ. (2006) Retrograde Transport is Significantly Reduced Prior to RGC Death in the DBA Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1237).

Sappington, RM., Calkins, DJ. (2006) TRPV1 Modulates Pressure-Induced Interleukin-6 Release by Retinal Microglia (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1266).

Carlson, BJ., Sappington, RM., Calkins, DJ.(2006) Metabotropic Glutamate Receptor 1 : Implications for Vascular Permeability in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1272).

Inman, DM., Horner, PJ. (2006) Potential Impact of Glial Hypertrophy and Proteoglycan Changes on Retinal Ganglion Cell Function in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1576).

Lambert, WS., Inman, DM., Horner, PJ. (2006) Ceruloplasmin Expression in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1241).

Calkins, DJ., Sappington, RM. (2005) Pressure-Induced Production of Inflammatory Cytokines and Activation of NF B Is Modulated by Calcium Channels in Retinal Glia (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3579).

Inman, DM., Buckingham, BP., Sappington, RM., Calkins, DJ., Horner, PJ.(2005) Retinal Vessel Volume and Pericyte Number Decrease Over Time in the DBA/2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 1320).

Steele, M., Inman, DM., Sappington, RM., Golestaneh, N., Marsh-Armstrong, N., Calkins, DJ., Horner, PJ., Vetter, ML. (2005) Whole Retinal Microarray Analysis of DBA/2J Mice: A Model for Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 48).

Buckingham, BP., Inman, D., Horner, PJ. (2005) RGC Cell Death or Axon Transport Defect in a Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3803).

Marsh-Armstrong, N., Hwang, H.-W., Steele, M., Callahan, E., Vetter, ML. (2005) Early Retina Progenitor Specific Expression of Frizzled-5 BAC and Enhancer (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3240).


Top of page