Glaucoma Publications & Abstracts
Scientific studies made possible by Glaucoma Research Foundation are changing the way doctors treat glaucoma — and speeding the search for a cure. Sharing these studies across the bioscience community ensures that today’s discoveries inspire and inform future research.
Video: How Do We Share Discoveries?
Drs. Monica Vetter and Nick Marsh-Armstrong — members of the first pioneering Catalyst for a Cure consortium — explain how their collaborative findings influence others in the quest for glaucoma innovation.
Monica Vetter, PhD: Citation is a very technical term, but it simply means that other scientists have read your work and they’ve thought about your work, and then they use that to inform what they’re going to do. And if they cite it, if they reference your work in their published papers, it means that they feel that the paper that they’re citing was an important concept that guided their subsequent experiments. And so as Dr. Horner said, it’s a barometer of what kind of influence the work is having in the field. Does it actually lead people to have new insights that then launches them in new directions and helps drive the field forward?
Nicholas Marsh-Armstrong, PhD: Having our work cited so often is evidence to us that we’re having a big impact, and I think that we know that already. So I think having our work cited so often by other scientists, many of whom we respect to a high degree, is just evidence to us that we’re having a big impact in driving the future of glaucoma research. I think that the Glaucoma Research Foundation’s vision in making this collaborative effort that we call “The Catalyst For a Cure” will have a long lasting impact on how glaucoma is studied in the future and how it will be treated in the future. So I think it was money well invested.
End of transcript.
“Having our work cited so often by other scientists, many of whom we respect to a high degree, is just evidence to us that we’re having a big impact in driving the future of glaucoma research.”
How do the results of glaucoma research conducted in the laboratory make their way into the world? Scientists publish their findings, making them accessible to other researchers, who build on them in their own work.
This exchange of knowledge starts with peer review, a scholarly process used in the publication of scientific research manuscripts. Peer review ensures high quality standards by subjecting an author’s work or ideas to the scrutiny of experts in the field. Each reviewer returns an evaluation of the manuscript, including suggestions for improvement, to an editor or other intermediary. Once research is refined and published, other scientists who take inspiration from the work will reference the study with a citation in their scientific report.
Studies supported by Glaucoma Research Foundation have been influential in and beyond the field of ophthalmology. Findings from our first Catalyst for a Cure initiative — the endeavor that redefined glaucoma as a neurological disorder, not just a disease of the eye — have been cited by other scientists more than 8,000 times. Each citation is a vote of confidence that our community’s investments in collaborative research are advancing the quest for a glaucoma cure and shaping the future of health care overall.
Publications and Abstracts
Following are selected peer-reviewed publications resulting from research made possible by grants from the Glaucoma Research Foundation.
To view the abstract of an article, copy the article name and paste it into the search box at the PubMed web site, www.pubmed.gov (a service of the National Library of Medicine and the National Institutes of Health).
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Adriana Di Polo, PhD, Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma, Science Advances, 7 August 2024, Vol 10 Issue 32
Colm O’Brien, MD, FRCS, AAV-NDI1 Therapy Provides Significant Benefit to Murine and Cellular Models of Glaucoma, International Journal of Molecular Sciences, 15 August 2024, vol. 25, no. 16: 8876
Teresa Puthussery, BOptom, PhD, Wang, A.Y.M., Kulkarni, M.M., McLaughlin, A.J., Gayet J, Smith BE, Hauptschein M, McHugh CF, Yao YY: An ON-type direction-selective ganglion cell in primate retina. Nature, October 25, 2023, pp. 381-386
Rachel W. Kuchtey, MD, PhD: Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice. Matrix Biology Plus, December 2022, Vol. 16
Pete A. Williams, PhD: Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction. Redox Biology, July 2021, Vol. 43, 101988
Pete A. Williams, PhD: Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial. Clinical & Experimental Ophthalmology, September 2020, pp. 903-914, Vol. 48 No. 7
Donald L. Budenz, MD, MPH: Eight-Year Incidence of Open-Angle Glaucoma in the Tema Eye Survey. Ophthalmology, March 2019, pp. 372-380, Vol. 126, No. 3
Evan B. Stubbs, Jr., PhD: Rho GTPase signaling promotes constitutive expression and release of TGF-β2 by human trabecular meshwork cells. Experimental Eye Research, May 2016, pp. 95-102, Vol. 146
Gulgun Tezel, PhD: Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina. Investigative Ophthalmology & Visual Science (IOVS), September 2015, 5816-5830, Vol. 56, No. 10
Derek S. Welsbie, MD, PhD: Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proceedings of the National Academy of Sciences, March 15, 2013, Vol. 35, pp. 56-65. European Journal of Neuroscience 2012, Vol. 110 no. 10, 4045-4050
Alexander C. Theos, PhD: The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB. Pigment Cell & Melanoma Research, March 4, 2013
William Baldridge, PhD: Functional evidence for D-serine inhibition of non-N-methyl-D-aspartate ionotropic glutamate receptors in retinal neurons. European Journal of Neuroscience 2012, Vol. 35, pp. 56-65
Janice Vranka, PhD: Segmental versican expression in the trabecular meshwork and involvement in outflow facility. Investigative Ophthalmology & Visual Science 2011; 52(8)
An Zhou, PhD: Retinal proteomic changes under different ischemic conditions – implication of an epigenetic regulatory mechanism. International Journal of Physiology, Pathophysiology and Pharmacology 2010; 2(2): 148-160
Deborah C. Otteson, PhD: A role for DNA methylation in regulation of EphA5 receptor expression in the mouse retina. Vision Research 2010, September 25
Raquel L. Lieberman, PhD: Rescue of Glaucoma-Causing Mutant Myocilin Thermal Stability by Chemical Chaperones. ACS Chemical Biology 2010, March 24
Kate E. Keller, PhD: Differential Effects of ADAMTS-1, -4, and -5 in the Trabecular Meshwork. Investigative Ophthalmology & Visual Science 2009; 50 (12)
Kate E. Keller, PhD: Extracellular matrix turnover and outflow resistance. Experimental Eye Research 2009; 88
Yutao Liu, MD: Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma. Molecular Vision 2008; 14
Brad Fortune, PhD: Relative course of retinal nerve fiber layer birefringence and thickness and retinal function changes after optic nerve transection. Investigative Ophthalmology & Visual Science 2008; 49:10
Keith Martin, MD: Development and characterization of an adult retinal explant organotypic tissue culture system as an in vitro intraocular stem cell transplantation model. Investigative Ophthalmology & Visual Science 2008; 49:8
Ruth Ashery-Padan, PhD: Dual requirement for Pax6 in retinal progenitor cells. Development 2008 135: 24
Jonathan Crowston, MD: Oxidative Stress Is an Early Event in Hydrostatic Pressure-Induced Retinal Ganglion Cell Damage. Investigative Ophthalmology & Visual Science 2007; 48:10
Sayoko E. Moroi, MD: Evaluation of the ß2-Adrenergic Receptor Gene as a Candidate Glaucoma Gene in 2 Ancestral Populations. Archives of Ophthalmology 2007 Jan;125:1.
Lin Wang, MD: Microspheres method for ocular blood flow measurement in rats: size and dose optimization. Experimental Eye Research 2007 84:1
Mark Filla, PhD: ß1 and ß3 Integrins Cooperate to Induce Syndecan-4 Containing Cross-Linked Actin Networks in Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 2006; 47:5
Michèle Sale, PhD: Confirmation of the Adult-Onset Primary Open Angle Glaucoma Locus GLC1B at 2cen-q13 in an Australian Family. Ophthalmologica 2006; 220:23-30
Philip Gage, PhD: Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye. Investigative Ophthalmology & Visual Science 2005; 46:11
Ernst Tamm, MD: Ectopic Norrin Induces Growth of Ocular Capillaries and Restores Normal Retinal Angiogenesis in Norrie Disease Mutant Mice. The Journal of Neuroscience 2005; 25:7
Michèle Sale, PhD: Linkage to 10q22 for Maximum Intraocular Pressure and 1p32 for Maximum Cup-to-Disx Ration in an Extended Primary Open-Angle Glaucoma Pedigree. Investigative Ophthalmology & Visual Science 2005; 46:10
Brad Fortune, OD, PhD: The Gradient of Retinal Functional Changes During Acute Intraocular Pressure Elevation. Investigative Ophthalmology & Visual Science 2005; 46:1
Joseph Caprioli, MD: Calpain and N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat retinas. Brain Research 2005; 1046(1-2):207-15 Luca Scorrano, MD, PhD: OPA1 Requires Mitofusin 1 to Promote Mitochondrial Fusion. PNAS 2004; 101:45
Michal Schwartz, PhD: Antigenic Specificity of Immunoprotective Therapeutic Vaccination for Glaucoma. Investigative Ophthalmology & Visual Science 2003; 44:8
Joseph Caprioli, MD: Hyperthermic pre-conditioning protects retinal neurons from N-methyl-D-aspartate (NDMA)-induced apoptosis in rat. Brain Research 2003;
Joseph Caprioli, MD: 2-Deoxy-D-glucose protects retinal ganglion cells against excititoxicity. NeuroReport; Vol 14 No 18 19 Dec 2003
Gülgün Tezel, MD: Immunohistochemical Assessment of the Glial Mitogen-Activated Protein Kinase Activation in Glaucoma. Investigative Ophthalmology & Visual Science 2003; 44:7
Edward Essock, PhD: Fourier Analysis of optical coherence Tomography and scanning laser polarimetry retinal nerve fiber layer measurements in the diagnosis of glaucoma. Archives of Ophthalmology 2003; 121:9
Ted S. Acott, PhD: Involvement of the Erk-MAP Kinase Pathway in TNFa Regulation of Trabecular Matrix Metalloproteinases and TIMPs. Investigative Ophthalmology & Visual Science 2003; 44:1
Ted S. Acott, PhD: Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch. Investigative Ophthalmology & Visual Science 2003; 44:12
Larry Benowitz, PhD: Macrophage-Derived Factors Stimulate Optic Nerve Regeneration. Journal of Neuroscience 2003; 23 (6): 2284-2293
Joseph Caprioli, MD: Retinal Ganglion Cell Protection with Geranylgeranylacetone, A Heat Shock Protein Inducer, in a Rat Glaucoma Model. Investigative Ophthalmology & Visual Science 2003; 44:5
Andrew Iwach, MD (GREG): Long-Term Results of Noncontact Transcleral Neodymium:YAG Laser Cyclophotocoagulation for Neovascular Glaucoma. Ophthalmology. 2003; 110(5):895-9.
Andrew Iwach, MD (GREG): Transconjunctival Mitomycin-C in Needle Revisions of Failed Filtering Blebs. Ophthalmology. 2003; 110(4):734-42.
Andrew Iwach, MD (GREG): Comparison of the Efficacy of the Fixed-Combination Timolol/Dorzolamide Versus Concomitant Administration of Timolol and Dorzolamide. Journal of Ocular Pharmacology and Therapeutics 2003; 19(2):93-6.
Michal Schwartz, PhD: Resistance of Retinal Ganglion Cells to an Increase in Intraocular Pressure is Immune-Dependent. Investigative Ophthalmology & Visual Science 2002; 43:8
Philip Gage, PhD: Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development. 2002; 129: 329
Henry Jampel, MD: Correlation of the Binocular Visual Field with Patient Assessment of Vision. Investigative Ophthalmology & Visual Science 2002; 43:4
Darryl Nishimura, PhD: Genetic Analysis of PITX2 and FOXC1 in Rieger Syndrome in Patients From Brazil. Journal of Glaucoma 2002; 11:51
Cassandra Schlamp, PhD: p53 regulated apoptotic retinal ganglion cell death induced by N-methyl-D-aspartate. Molecular Vision 2002; 8:341-350
Haiyan Gong, MD, PhD: The Mechanism of Increasing Outflow Facility during Washout in the Bovine Eye. Investigative Ophthalmology & Visual Science 2002; 43:11
Stanislav I. Tomarev, PhD: Optimedin: A Novel olfactomedin-related protein that interacts with myocilin. Human Molecular Genetics 2002; 11:11
Christopher Bowd, PhD: Comparing Neural Networks and Linear Discriminant Functions for Glaucoma Detection using Confocal Scanning Laser Ophthalmoscopy of the Optic Disc. Investigative Ophthalmology & Visual Science 2002; 43:11
Andrew Iwach (GREG): Long-Term Follow-Up of Initially Successful Trabeculectomy with 5-Fluorouracil Injections. Ophthalmology 2002;109(10):1921-4.
Andrew Iwach, MD (GREG): Filtering Bleb Modification with a THC:YAG (Holmium) Laser. Ophthalmic Surgery and Lasers 2002 May-Jun;33(3):181-7.
Michal Schwartz, PhD: Self-Protecting Mechanism awakened by Glutamate in Retinal Ganglion Cells. Journal of Neurotrauma 2001; Vol. 18:339
Darryl Nishimura, PhD: A Spectrum of FOXC1 Mutations Suggests Gene Dosage as a Mechanism for Developmental Defects of the Anterior Chamber of the Eye. American Journal of Human Genetics 2001; 68:364
Cassandra Schlamp, PhD: Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Molecular Vision 2001; 7:192-201
Terete Borras, PhD: Inefficient Processing of an Olfactomedin-Deficient Myocilin Mutant: Potential Physiological Relevance to Glaucoma. Biochemical and Biophysical Research Communications 2001; 282 662-670
Gülgün Tezel, MD: Serum Autoantibodies to Heat Shock Proteins in Glaucoma Patients from Japan and the US. Ophthalmology 2001; 108:296-302
Gülgün Tezel, MD: Induction of HLA-DR Expression in Human Lamina Cribrosa Astrocytes by Cytokines and Simulated Ischemia. Investigative Ophthalmology & Visual Science 2001; 42:2
Gülgün Tezel, MD: In Vitro Evaluation of Reactive Astrocyte Migration, A Component of Tissue Remodeling in Glaucomatous Optic Nerve Head. GLIA 2001; 34:178-189
Gülgün Tezel, MD: Serum Autoantibody against Glutathione S-Transferase in Patients with Glaucoma. Investigative Ophthalmology & Visual Science 2001; 42:6
Gülgün Tezel, MD: Clinical Factors Associated with Progression of Glaucomatous Optic Disc Damage in Treated Patients. Archives of Ophthalmology 2001; Vol. 119
Gülgün Tezel, MD: TNF- and TNF- Receptor-1 in the Retina of Normal and Glaucomatous Eyes. Investigative Ophthalmology & Visual Science 2001; 42:8
Joseph Caprioli, MD: Induction of Heat Shock Protein 72 in Retinal Ganglion Cells of a Rat Glaucoma Model. Investigative Ophthalmology & Visual Science 2001; 42:0
Michal Schwartz, PhD: Vaccination for Neuroprotection in the Mouse Optic Nerve: Implications for Optic Neuropathies. Journal of Neuroscience 2001; Vol. 21(1) 136-42
Michal Schwartz, PhD: Vaccination for Protection of Retinal Ganglion Cells Against Death from Glutamate Cytotoxicity and Ocular Hypertension: Implications for Glaucoma. Proc. National Academy of Sciences USA 2001; 98:6
Donald Zack, MD: Obstructed Axonal Transport of BDNF and its Receptor TrkB in Experimental Glaucoma. Investigative Ophthalmology & Visual Science 2000; 41:3
Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: GLC1F, A New Primary Open-angle Glaucoma Locus, Maps to 7q35-q36. Archives of Ophthalmology 1999; Vol. 117
Jorge Alvarado, MD; Johnnie Underwood, PhD: Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. AJP-Cell Physiology 1999; Vol. 277:2
James Brandt, MD; Martha O’Donnell, PhD: How Does the Trabecular Meshwork Regulate Outflow? Clues From the Vascular Endothelium. Journal of Glaucoma 1999; 8:328-339
James Brandt, MD; Martha O’Donnell, PhD: Effects of Na-K-2Cl Cotransport Regulators on Outflow Facility in Calf and Human Eyes in Vitro. Investigative Ophthalmology & Visual Science 1999; 40:8
James Brandt, MD; Martha O’Donnell, PhD: Na-K-2Cl Cotransport in Normal and Glaucomatous Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 1999; 40:2
Paul Kaufman, MD:_ H-7 Increases Trabecular Facility and Facility after Ciliary Muscle Disintertion._ Investigative Ophthalmology & Visual Science 1999, 40:1
Paul Kaufman, MD: Latrunculin-A Causes Mydriasis and Cycloplegia in the Cynomolgus Monkey. Investigative Ophthalmology & Visual Science 1999; 40:3
Paul Kaufman, MD: Effect of Staurosporine on Outflow Facility in Monkeys. Investigative Ophthalmology & Visual Science 1999; 40:5
Paul Kaufman, MD: Latrunculin-A Increases Outflow Facility in the Monkey. Investigative Ophthalmology & Visual Science 1999; 40:5
Robert Wordinger, PhD: Expression of Alternatively Spliced Growth Factor Receptor Isoforms in the Human Trabecular Meshwork. Investigative Ophthalmology & Visual Science 1999; 40:1
Robert Wordinger, PhD: Fas-Activated Apoptosis and Apoptosis Mediators in Human Trabecular Meshwork Cells. Experimental Eye Research 1999; Vol. 68 583-590
Robert Wordinger, PhD: Effects of Glucocorticoids on the Trabecular Meshwork: Towards a Better Understanding of Glaucoma. Progression Retina & Eye Research 1999; Vol. 18:5
Robert Nickells, PhD: Experimental Induction of Retinal Ganglion Cell Death in Adult Mice. Investigative Ophthalmology & Visual Science 1999; 40:5
Martin Wax, MD: Effects of Methotrexate Treatment on Serum Immunoreactivity of a Patient with Normal-Pressure Glaucoma. American Journal of Ophthalmology June 1999
Martin Wax, MD: Serum Autoantibodies to Optic Nerve Head Glycosaminoglycans in Patients with Glaucoma. Archives of Ophthalmology 1999; V.117
Martin Wax, MD: The Effects of Fludrocortisone on Retrobulbar Hemdynamic Parameters in Normal Pressure Glaucoma Patients with Low Blood Pressure. Annals of Ophthalmology 1999; 31:3
Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Insulin-Like Growth Factor Binding Protein-5 Expression by Human Trabecular Meshwork. Investigative Ophthalmology & Visual Science 1998; 39:1
Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Prospects for Genetic Intervention in Primary Open-angle Glaucoma. Drugs & Aging 1998; 13:5
R. Rand Allingham, MD; Janey Wiggs, MD: Gln368STOP Myocilin Mutation in Families with Late -Onset Primary Open Angle Glaucoma. Investigative Ophthalmology & Visual Science 1998; 39:12
W. Lee Alward, MD: The Forkhead Transcription Factor Gene FKHL7 is responsible for Glaucoma Phenotypes which Map to 6p25. Nature Genetics 1998; 19: 140
W. Lee Alward, MD: Clinical Features Associated with Mutations in the Chromosome 1 Open-Angle Glaucoma Gene. New England Journal of Medicine 1998; 338:1022
Ted Acott, PhD: Growth Factor and Cytokine Modulation of Trabecular Meshwork Matrix Metalloproteinase and TIMP Expression. Current Eye Research, 1998; 17:276-285
Ted Acott, PhD: Insulin-Like Growth Factor Binding Protein-5 Expression by Human Trabecular Meshwork. Investigative Ophthalmology & Visual Science 1998; 39:1
Ted Acott, PhD: Effect of Matrix Metalloproteinases Activity on Outflow in Perfused Human Organ Culture. Investigative Ophthalmology & Visual Science 1998; 39:13
Jorge Alvarado, MD; Johnnie Underwood, PhD: Effect of b-Adrenergic Agonists on Paracellular Width and Fluid Flow across Outflow Pathway Cells. Investigative Ophthalmology & Visual Science 1998, 39:10
David Epstein, MD: Mechanical Stretch Alters the Actin Cytoskeletal Network and Signal Transduction in Human Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 1998; 39:8
Paul Kaufman, MD: H-7 Disrupts the Actin Cytoskeleton and Increases Outflow Activity. Archives of Ophthalmology 1998; Vol. 116
Paul Kaufman, MD: Effects of H-7 on the Iris and Ciliary Muscle in Monkeys. Archives of Ophthalmology 1998; Vol. 116
John Polansky, MD; Thai Nguyen, PhD: Gene Structure and Properties of an Olfactomedin-related Glycoprotein, TIGR, Cloned from Glucocorticoid-induced Trabecular Meshwork Cells. Journal of Biological Chemistry 1998
John Polansky, MD; Thai Nguyen, PhD: The TIGR Gene, Pathogenic mechanisms, and other recent advances in glaucoma genetics. Current Opinion in Ophthalmology 1998; 9(11) 15-23
Robert Wordinger, PhD: Cultured Human Trabecular Meshwork Cells Express Functional Growth Factor Receptors. Investigative Ophthalmology & Visual Science 1998; 39:9
Evan Dreyer, MD: A Proposed Role for Excitotoxicity in Glaucoma. Journal of Glaucoma 1998; 7:62-67
Evan Dreyer, MD: Nitrate Therapy may retard glaucomatous optic neropathy, perhaps through modulation of glutamate receptors. Vision Research 1998; 38:1489-1494
Martin Wax, MD: Anti-Ro/SS- A Positivity and Heat Shock Protein Antibodies in Patients with Normal -pressure glaucoma. American Journal of Ophthalmology 1998; 125:2
Martin Wax, MD: Clinical and Ocular Histopathological Findings in a Patient With Normal-Pressure Glaucoma. Archives Of Ophthalmology 1998; V.116
Martin Wax, MD: Autoantibodies to Small Heat Shock Proteins in Glaucoma. Investigative Ophthalmology & Visual Science 1998; 39:12
Andrew Iwach, MD (GREG): Endoscopic Diode Laser Cyclophotocoagulation via a Limbal Approach. Ophthalmic Surgery and Lasers 1997 Feb;28(2):118-23.
Andrew Iwach, MD (GREG): Clinical Experience of Trabeculotomy for the Surgical Treatment of Aniridic Glaucoma. Ophthalmology 1997 Dec;104(12):2121-5.
Martin Wax, MD: Vacuolar H+ -ATPase in ocular ciliary epithelium. Proc. National Academy of Sciences 1997; 94: 6752-6757
Martin Wax, MD: Parapapillary Chorioretinal Atrophy in Patients With Ocular Hypertension I. Archives Of Ophthalmology 1997; V.115
Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Manipulation of Matrix Metalloproteinase Activity Modulates Outflow in Perfused Human Organ Culture. Investigative Ophthalmology & Visual Science 1997
Douglas Anderson, MD: Reproducibility of Laser Doppler Flowmetry in the Human Optic Nerve Head. Journal of Glaucoma 1997; 6: 212-216
Evan Dreyer, MD: Amino Acid Abnormalities in the Vitreous of the Buphthalmic Rabbit. Veterinary & Comparative Ophthalmology 1997; 7:3
Evan Dreyer, MD: The Role of Neuronal and Endothelial Nitric Oxide Synthase in Retinal Excitotoxicity. Association for Research in Vision and Ophthalmology 1997; 38:10
Evan Dreyer, MD: Molecular Basis of Glutamate Toxicity in Retinal Ganglion Cells. Vision Research 1997; 37:24
M. Rosario Hernandez, DDS: Hyaluronic Acid in the Normal and Glaucomatous Optic Nerve. Experimental Eye Research 1997; 64: 587-595
M. Rosario Hernandez, DDS: Astrocyte Responses in Human Optic Nerve Head with Primary Open-Angle Glaucoma. Journal of Glaucoma 1997; 6: 103-313
James Brandt, MD; Martha O’Donnell, PhD: Effects of Dexamethasone On Na-K-Cl Cotransport in Trabecular Meshwork Cells. Investigative Ophthalmology & Visual Science 1997; 38:6
David Epstein, MD: Signal Transduction in Human Trabecular Meshwork Cells. Ocular Cell and Molecular Biology January 1997
Douglas Johnson, MD; Paul Russell, PhD: Ultrastructural Changes in the Trabecular Meshwork of Human Eyes Treated with Corticosteroids. Archives of Ophthalmology March 1997; Vol. 115
John Polansky, MD; Thai Nguyen, PhD: Glaucoma Gene Provides Light at the End of the Tunnel. Science 1997; Vol. 275
John Polansky, MD; Thai Nguyen, PhD: Identification of a Gene That Causes Primary Open Angle Glaucoma. Science 1997; Vol 275 pp. 668-670
John Polansky, MD; Thai Nguyen, PhD: Cellular Pharmacology and Molecular Biology of the Trabecular Meshwork Inducible Glucocorticoid Reponse Gene Product. Ophthalmology 1997; 211: pp. 126-139
Douglas Johnson, MD; Paul Russell. PhD: Enzymes Protective of Oxidative Damage Present in all Decades of Life in The Trabecular Meshwork, as Detected by Two-Dimensional Gel Electrophoresis Protein Maps. Journal of Glaucoma 1996; 5: 317-324
Paul Kaufman, MD; Mark Johnson, PhD; Thomas Freddo, PhD: IOP and Outflow Facility are Unchanged Following Acute and Chronic Intracameral Chondroitinase ABC and Hyaluronidase in Monkeys. Investigative Ophthalmology & Visual Science 1996; 37:3
Mary Wirtz, PhD; Ted Acott, PhD; Max Cynader, PhD: Proteoglycan expression by human trabecular meshworks. Current Eye Research December 19, 1996
Douglas Anderson, MD: Laser Doppler Flowmetry Measurement of Changes in Human Optic Nerve Head Blood Flow in Response to Blood Gas Peturbations. Journal of Glaucoma 1996; 5 (4): 258-265
Douglas Anderson, MD: Dynamic Response of Optic Nerve Head Blood Flow to Increased Intraocular Pressure. Investigative Ophthalmology & Visual Science 1996; 37:3
Evan Dreyer, MD: Elevated Glutamate Levels in the Vitreous Body of Humans. Archives of Ophthalmology 1996; V.114
Paul Kaufman, MD: Latrunculin LAT-A and Staurosporine, But not Swinholide (SWIN) -A, Increase Outflow Facility in the Monkey. Investigative Ophthalmology & Visual Science 1996; 37:3
Paul Kaufman, MD: The Protein kinase inhibitor H-7 increases outflow facility and inhibits miotic but not accommodative responses to pilocarpine in monkeys. Investigative Ophthalmology & Visual Science 1996; 37:3
Andrew Iwach, MD (GREG): Trabeculectomy with Intraoperative Sponge 5-Flourouracil. Ophthalmology 1996 Jun;103(6):963-70.
Andrew Iwach, MD (GREG): Update of the Subconjuctival THC:YAG (Holmium) Laser Sclerostomy Ab Externo Clinical Trail: 4-Year Report. Ophthalmic Surgery and Lasers 1996, 27:823.
Andrew Iwach, MD (GREG): A High Prevalence of Occludable Angles in a Vietnamese Population. Ophthalmology 1996, Vol. 103, No. 9.
Douglas Anderson, MD: Autoregulation of Human Optic Nerve Head Circulation in Response to Increased Intraocular Pressure. Investigative Ophthalmology & Visual Science 1995; 36(4)
Andrew Iwach, MD (GREG): Long-term Results of Noncontact Transscleral Neodymium:YAG Cyclophotocoagulation. Ophthalmology 1995, Vol. 102, No. 12.
The Catalyst for a Cure Initiative to Prevent and Cure Neurodegeneration scientists (CFC 4) have received important peer acknowledgment in key science publications. The following list of publications and abstracts represents research results published since 2022.
Single-cell transcriptome of retinal myeloid cells in response to transplantation of human neurons reveals reversibility of microglial activation. Kriukov, Emil; Mukwaya, Anthony; Cullen, Paul Francis; Baldwin, George; Malechka, Volha V.; Refaian, Nasrin; Bagaev, Nikita; Labrecque, Everett; Vinjamuri, Sthavir; Margeta, Milica A.; Baranov, Petr. bioRxiv. 2025. (); 2025.05.16.654622.DOI: 10.1101/2025.05.16.654622. PMID: 40475635. PMCID: PMC12139861. (In press.)
Electrochemical response of biological membranes to localized currents and external electric fields. Fernandes, Joshua B.; Row, Hyeongjoo; Mandadaou, Kranthi K., Shekhar, K. arXiv preprint arXiv:2508.14001. 2025. (In press)
Cholinergic waves have a modest influence on the transcriptome of retinal ganglion cells. Somaiya, Rachana Deven; Po, Matthew A.; Feller, Marla B.; Shekhar, Karthik. Journal of Neuroscience. 2025.45(35) e0165252025 https://doi.org/10.1523/JNEUROSCI.0165-25.2025 PMID: 40695599
Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression. Savchuk, Solomiia; Gentry, Kaylee; Wang, Wengang; Carleton, Elana; Yalçın, Belgin; Liu, Yin; Pavarino, Elisa C.; LaBelle, Jenna; Toland, Angus M.; Woo, Pamelyn J.; Qu, Fangfei; Filbin, Mariella G.; Krasnow, Mark A.; Sabatini, Bernardo L.; Sage, Julien; Monje, Michelle; Venkatesh, Humsa S. Nature. 2025 Sep 10. DOI: 10.1038/s41586-025-09492-z. PMID: 40931074
Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex. Xie, Fangming; Jain, Saumya; Xu, Runzhe; Butrus, Salwan; Tan, Zhiqun; Xu, Xiangmin; Shekhar, Karthik; Zipursky, S Lawrence. Proceedings of the National Academy of Sciences. 2025 122(7), p.e2421022122. DOI: 10.1073/pnas.2421022122. PMID: 39946537. PMCID: PMC11848306
Comparative transcriptomic insights into the evolution of vertebrate photoreceptor types. Tommasini, Dario; Yoshimatsu, Takeshi; Puthussery, Teresa; Baden, Tom; Shekhar Karthik. Current Biology 2025 35(10): 2228-2239. PMID: 40250432
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Savchuk, Solomiia; Gentry, Kaylee M.; Wang, Wengang; Carleton, Elana; Biagi-Junior, Carlos A. O.; Luthria, Karan; Yalçın, Belgin; Ni, Lijun; Farnsworth, Hannah C.; Davis, Rachel A.; Drexler, Richard; Melms, Johannes C.; Liu, Yin; Acosta-Alvarez, Lehi; Hartmann, Griffin G.; Pavarino, Elisa C.; LaBelle, Jenna; Woo, Pamelyn J.; Toland, Angus M.; Qu, Fangfei; Kim, Yoon Seok; Filbin, Mariella G.; Krasnow, Mark A.; Ligon, Keith L.; Izar, Benjamin; Sage, Julien; Sabatini, Bernardo L.; Monje, Michelle; Venkatesh, Humsa S. Nature. 2025. DOI: 10.1038/s41586-025-09492-z. PMID: 40931074.
Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma. Nimkar, Kushal; Tsai, Nicole Y; Zhao, Mengya; Yi, Yujuan; Lum, Matthew R; Garrett, Tavita R; Wang, Yixiao; Toma, Kenichi; Caval-Holme, Franklin; Reddy, Nikhil; Ehrlich, Aliza T; Kriegstein, Arnold R; Do, Michael Tri H; Hu, Yang; Sivyer, Benjamin; Shekhar, Karthik; Duan, Xin. Neuron. 2025. DOI: 10.1016/j.neuron.2025.07.025. PMID: 40840447.
CSF transport at the brain–meningeal border: effects on neurological health and disease. Pinho-Correia, Liliana M; McCullough, Samuel J C; Ghanizada, Hashmat; Nedergaard, Maiken; Rustenhoven, Justin; Da Mesquita, Sandro. The Lancet Neurology. 2025. 24(6); 535-547.DOI: 10.1016/s1474-4422(25)00115-2. PMID: 40409317. PMCID: PMC12315021.
“Optic nerve of steel”: A case of very high intraocular pressures with markedly little visual field progression over years. Xue, Yixi; Margeta, Milica A. American Journal of Ophthalmology Case Reports. 2025. 38(); 102325.DOI: 10.1016/j.ajoc.2025.102325. PMID: 40265087. PMCID: PMC12013393.
Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma. Lin, Jonathan B.; Helwe, Hani El; Falah, Henisk; Hammerschlag, Bruno L.; Schultz, Stephanie A.; Baldwin, George; Xue, Yixi; Vasan, Ryan A.; Song, Christian; Lo, Kristine; Meeker, Austin; Wang, Silas L.; Kivisäkk, Pia; Valle, David Solá-Del; Margeta, Milica A. Translational Vision Science & Technology. 2025. 14(2); 24.DOI: 10.1167/tvst.14.2.24. PMID: 39998458. PMCID: PMC11875033.
Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex. Xie, Fangming; Jain, Saumya; Xu, Runzhe; Butrus, Salwan; Tan, Zhiqun; Xu, Xiangmin; Shekhar, Karthik; Zipursky, S. Lawrence. Proceedings of the National Academy of Sciences of the United States of America. 2025. 122(7); e2421022122.DOI: 10.1073/pnas.2421022122. PMID: 39946537. PMCID: PMC11848306.
Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference. Kloske, Courtney M.; Mahinrad, Simin; Barnum, Christopher J.; Batista, Andre F.; Bradshaw, Elizabeth M.; Butts, Brittany; Carrillo, Maria C.; Chakrabarty, Paramita; Chen, Xiaoying; Craft, Suzanne; Da Mesquita, Sandro; Dabin, Luke C.; Devanand, Davangere; Duran‐Laforet, Violeta; Elyaman, Wassim; Evans, Elizabeth E.; Fitzgerald‐Bocarsly, Patricia; Foley, Kate E.; Harms, Ashley S.; Heneka, Michael T.; Hong, Soyon; Huang, Yu‐Wen A.; Jackvony, Stephanie; Lai, Laijun; Le Guen, Yann; Lemere, Cynthia A.; Liddelow, Shane A.; Martin‐Peña, Alfonso; Orr, Anna G.; Quintana, Francisco J.; Ramey, Grace D.; Rexach, Jessica E.; Rizzo, Stacey J. S.; Sexton, Claire; Tang, Alice S.; Torrellas, Jose G.; Tsai, Andy P.; van Olst, Lynn; Walker, Keenan A.; Wharton, Whitney; Tansey, Malú Gámez; Wilcock, Donna M. Alzheimer’s & Dementia. 2024. 21(1); e14291.DOI: 10.1002/alz.14291. PMID: 39692624. PMCID: PMC11772715.
Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes. Al-Diwani, Adam; Provine, Nicholas M; Murchison, Andrew; Laban, Rhiannon; Swann, Owen J; Koychev, Ivan; Sheerin, Fintan; Da Mesquita, Sandro; Heslegrave, Amanda; Zetterberg, Henrik; Klenerman, Paul; Irani, Sarosh R. Brain. 2024. 148(2); 394-400.DOI: 10.1093/brain/awae329. PMID: 39432679. PMCID: PMC11788199.
Ocular effects of Rho kinase (ROCK) inhibition: a systematic review. Lin, Jonathan B.; Harris, James M.; Baldwin, George; Goss, Deborah; Margeta, Milica A. Eye. 2024. 38(18); 3418-3428.DOI: 10.1038/s41433-024-03342-4. PMID: 39285241. PMCID: PMC11621399.
Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination. das Neves, Sofia P; Delivanoglou, Nickoleta; Ren, Yingxue; Cucuzza, Chiara Starvaggi; Makuch, Mateusz; Almeida, Francisco; Sanchez, Guadalupe; Barber, Megan J; Rego, Shanon; Schrader, Racquelle; Faroqi, Ayman H; Thomas, Jean-Leon; McLean, Pamela J; Oliveira, Tiago Gil; Irani, Sarosh R; Piehl, Fredrik; Da Mesquita, Sandro. Immunity. 2024. 57(10); 2328-2343.e8.DOI: 10.1016/j.immuni.2024.08.004. PMID: 39217987. PMCID: PMC11464205.
Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease. Da Mesquita, Sandro; Rua, Rejane. Trends in Immunology. 2024. 45(5); 346-357. DOI: 10.1016/j.it.2024.03.007. PMID: 38632001. PMCID: PMC11088519.
Evolution of neuronal cell classes and types in the vertebrate retina. Hahn, Joshua; Monavarfeshani, Aboozar; Qiao, Mu; Kao, Allison H.; Kölsch, Yvonne; Kumar, Ayush; Kunze, Vincent P.; Rasys, Ashley M.; Richardson, Rose; Wekselblatt, Joseph B.; Baier, Herwig; Lucas, Robert J.; Li, Wei; Meister, Markus; Trachtenberg, Joshua T.; Yan, Wenjun; Peng, Yi-Rong; Sanes, Joshua R.; Shekhar, Karthik. Nature. 2023. 624(7991); 415-424.DOI: 10.1038/s41586-023-06638-9. PMID: 38092908. PMCID: PMC10719112.
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints. Yin, Zhuoran; Rosenzweig, Neta; Kleemann, Kilian L.; Zhang, Xiaoming; Brandão, Wesley; Margeta, Milica A.; Schroeder, Caitlin; Sivanathan, Kisha N.; Silveira, Sebastian; Gauthier, Christian; Mallah, Dania; Pitts, Kristen M.; Durao, Ana; Herron, Shawn; Shorey, Hannah; Cheng, Yiran; Barry, Jen-Li; Krishnan, Rajesh K.; Wakelin, Sam; Rhee, Jared; Yung, Anthony; Aronchik, Michael; Wang, Chao; Jain, Nimansha; Bao, Xin; Gerrits, Emma; Brouwer, Nieske; Deik, Amy; Tenen, Daniel G.; Ikezu, Tsuneya; Santander, Nicolas G.; McKinsey, Gabriel L.; Baufeld, Caroline; Sheppard, Dean; Krasemann, Susanne; Nowarski, Roni; Eggen, Bart J. L.; Clish, Clary; Tanzi, Rudolph E.; Madore, Charlotte; Arnold, Thomas D.; Holtzman, David M.; Butovsky, Oleg. Nature Immunology. 2023. 24(11); 1839-1853.DOI: 10.1038/s41590-023-01627-6. PMID: 37749326. PMCID: PMC10863749.
Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease. Rego, Shanon; Sanchez, Guadalupe; Da Mesquita, Sandro. Molecular Neurodegeneration. 2023. 18(1); 55.DOI: 10.1186/s13024-023-00645-0. PMID: 37580702. PMCID: PMC10424377.
Targeting electrochemical communication between neurons and cancer. Venkatesh, Humsa S. Science Translational Medicine. 2023. 15(706); eadi5170.DOI: 10.1126/scitranslmed.adi5170. PMID: 37494471.
Defining Selective Neuronal Resilience and Identifying Targets of Neuroprotection and Axon Regeneration Using Single-Cell RNA Sequencing: Computational Approaches. Butrus, Salwan; Sagireddy, Srikant; Yan, Wenjun; Shekhar, Karthik. Methods in Molecular Biology. 2023. 2636; 19-41.DOI: 10.1007/978-1-0716-3012-9_2. PMID: 36881293.
Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease. Pitts, Kristen M.; Margeta, Milica A. Frontiers in Cellular Neuroscience. 2023. 17; 1106547.DOI: 10.3389/fncel.2023.1106547. PMID: 36779012.PMCID: PMC9909491.
Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma. Pitts, Kristen M; Neeson, Cameron E; Hall, Nathan E; Lin, Jonathan B; Falah, Henisk K; Wang, Silas L; Lo, Kristine T; Song, Christian E; Margeta, Milica A; Solá-Del Valle, David A. Translational Vision Science & Technology. 2022. 11(11); 1. DOI: 10.1167/tvst.11.11.1. PMID: 36318198. PMCID: PMC9639679.
Solving neurodegeneration: common mechanisms and strategies for new treatments. Wareham, Lauren K.; Liddelow, Shane A.; Temple, Sally; Benowitz, Larry I.; Di Polo, Adriana; Wellington, Cheryl; Goldberg, Jeffrey L.; He, Zhigang; Duan, Xin; Bu, Guojun; Davis, Albert A.; Shekhar, Karthik; Torre, Anna La; Chan, David C.; Canto-Soler, M. Valeria; Flanagan, John G.; Subramanian, Preeti; Rossi, Sharyn; Brunner, Thomas; Bovenkamp, Diane E.; Calkins, David J. Molecular Neurodegeneration. 2022. 17(1); 23.DOI: 10.1186/s13024-022-00524-0. PMID: 35313950. PMCID: PMC8935795.
The Catalyst for a Cure Vision Restoration team of scientists (CFC 3) has received important peer acknowledgment in key science publications. The following list of publications and abstracts represents research results published since 2019.
Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma. Nimkar, Kushal; Tsai, Nicole Y; Zhao, Mengya; Yi, Yujuan; Lum, Matthew R; Garrett, Tavita R; Wang, Yixiao; Toma, Kenichi; Caval-Holme, Franklin; Reddy, Nikhil; Ehrlich, Aliza T; Kriegstein, Arnold R; Do, Michael Tri H; Hu, Yang; Sivyer, Benjamin; Shekhar, Karthik; Duan, Xin. Neuron. 2025. DOI: 10.1016/j.neuron.2025.07.025. PMID: 40840447.
A neurobiology perspective on the assembly of retinal vasculature from 2D to 3D. Bose, Mahima; Zhao, Mengya; Toma, Kenichi; Ye, Xin; Duan, Xin. Current Opinion in Neurobiology. 2025. 93; 103085.DOI: 10.1016/j.conb.2025.103085. PMID: 40669155.
GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection. Yang, Ming; Bian, Fuyun; Feng, Xue; Li, Liang; Huang, Haoliang; Liu, Liang; Dalal, Roopa; Yang, Hang; Suraparaju, Pranav Varma; Cao, Frank; Ong, Petrina; Luo, Alexandria; Liu, Dong; Hu, Yang. bioRxiv. 2025.06.03.657677.DOI: 10.1101/2025.06.03.657677. PMID: 40501672. PMCID: PMC12157684. (in press)
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration. Liu, Dong; Webber, Hannah C.; Bian, Fuyun; Xu, Yangfan; Prakash, Manjari; Feng, Xue; Yang, Ming; Yang, Hang; You, In-Jee; Li, Liang; Liu, Liping; Liu, Pingting; Huang, Haoliang; Chang, Chien-Yi; Liu, Liang; Shah, Sahil H.; La Torre, Anna; Welsbie, Derek S.; Sun, Yang; Duan, Xin; Goldberg, Jeffrey Louis; Braun, Marcus; Lansky, Zdenek; Hu, Yang. Nature Communications. 2025. 16(1); 1789.DOI: 10.1038/s41467-025-57135-8. PMID: 39979261. PMCID: PMC11842812.
Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers. Lum, Matthew R.; Patel, Sachin H.; Graham, Hannah K.; Zhao, Mengya; Yi, Yujuan; Li, Liang; Yao, Melissa; La Torre, Anna; Della Santina, Luca; Han, Ying; Hu, Yang; Welsbie, Derek S.; Duan, Xin. bioRxiv. 2024.12.24.630272.DOI: 10.1101/2024.12.24.630272. PMID: 39763956. PMCID: PMC11703203. (in press)
Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma. Nimkar, Kushal; Tsai, Nicole Y; Zhao, Mengya; Yi, Yujuan; Lum, Matthew R; Garrett, Tavita R; Wang, Yixiao; Toma, Kenichi; Caval-Holme, Franklin; Reddy, Nikhil; Ehrlich, Aliza T; Kriegstein, Arnold R; Do, Michael Tri H; Hu, Yang; Sivyer, Benjamin; Shekhar, Karthik; Duan, Xin. Neuron. 2025. DOI: 10.1016/j.neuron.2025.07.025. PMID: 40840447.
Primary cilia formation requires the Leigh syndrome–associated mitochondrial protein NDUFAF2. Lo, Chien-Hui; Liu, Zhiquan; Chen, Siyu; Lin, Frank; Berneshawi, Andrew R.; Yu, Charles Q.; Koo, Euna B.; Kowal, Tia J.; Ning, Ke; Hu, Yang; Wang, Won-Jing; Liao, Y. Joyce; Sun, Yang. Journal of Clinical Investigation. 2024. 134(13); e175560.DOI: 10.1172/jci175560. PMID: 38949024. PMCID: PMC11213510.
Gene Expression and Editing in Mammalian Retinal Ganglion Cells. Tran, Nicholas M.; Xu, Xiaoshu; Qi, Lei S.; Hu, Yang. Essentials in Ophthalmology. 2024. 295-327.DOI: 10.1007/978-981-99-4436-1_19.
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration. Liu, Dong; Webber, Hannah C; Bian, Fuyun; Xu, Yangfan; Prakash, Manjari; Feng, Xue; Yang, Ming; Yang, Hang; You, In-Jee; Li, Liang; Liu, Liping; Liu, Pingting; Huang, Haoliang; Chang, Chien-Yi; Liu, Liang; Shah, Sahil H; Torre, Anna La; Welsbie, Derek S; Sun, Yang; Duan, Xin; Goldberg, Jeffrey L; Braun, Marcus; Lansky, Zdenek; Hu, Yang. Nature Communications. 2025 Feb 20;16(1):1789. doi: 10.1038/s41467-025-57135-8. PMID: 39979261. PMCID: PMC11842812
Mechanical Disruption of the Inner Limiting Membrane In Vivo Enhances Targeting to the Inner Retina. L., Jiun; Pedroarena-Leal, Nicole; Louie, Mikaela; Garcia, Paula Avila; Alnihmy, Adam; Patel, Amit; Weinreb, Robert N.; Wahlin, Karl J.; La Torre Vila, Anna; Welsbie, Derek S. Investigative Ophthalmology & Visual Science. 2023. 64(15); 25.DOI: 10.1167/iovs.64.15.25. PMID: 38117244. PMCID: PMC10741092.
Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming. Agarwal, Devansh; Dash, Nicholas; Mazo, Kevin W.; Chopra, Manan; Avila, Maria P.; Patel, Amit; Wong, Ryan M.; Jia, Cairang; Do, Hope; Cheng, Jie; Chiang, Colette; Jurlina, Shawna L.; Roshan, Mona; Perry, Michael W.; Rho, Jong M.; Broyer, Risa; Lee, Cassidy D.; Weinreb, Robert N.; Gavrilovici, Cezar; Oesch, Nicholas W.; Welsbie, Derek S.; Wahlin, Karl J.. npj Regenerative Medicine. 2023. 8(1); 55.DOI: 10.1038/s41536-023-00327-x. PMID: 37773257. PMCID: PMC10541876.
Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Soucy, Jonathan R.; Aguzzi, Erika A.; Cho, Julie; Gilhooley, Michael James; Keuthan, Casey; Luo, Ziming; Monavarfeshani, Aboozar; Saleem, Meher A.; Wang, Xue-Wei; Wohlschlegel, Juilette; Baranov, Petr; Di Polo, Adriana; Fortune, Brad; Gokoffski, Kimberly K.; Goldberg, Jeffrey L.; Guido, William; Kolodkin, Alex L.; Mason, Carol A.; Ou, Yvonne; Reh, Thomas A.; Ross, Ahmara G.; Samuels, Brian C.; Welsbie, Derek; Zack, Donald J.; Johnson, Thomas V.. Molecular Neurodegeneration. 2023. 18(1); 64.DOI: 10.1186/s13024-023-00655-y. PMID: 37735444. PMCID: PMC10514988.
Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy. Zhao, Mengya; Toma, Kenichi; Kinde, Benyam; Li, Liang; Patel, Amit K; Wu, Kong-Yan; Lum, Matthew R; Tan, Chengxi; Hooper, Jody E; Kriegstein, Arnold R; La Torre, Anna; Liao, Yaping Joyce; Welsbie, Derek S; Hu, Yang; Han, Ying; Duan, Xin. Cell Reports. 2023. 42(9); 113038.DOI: 10.1016/j.celrep.2023.113038. PMID: 37624696. PMCID: PMC10591811.
Silicone Oil-Induced Ocular Hypertension Glaucoma Model (SOHU) in Rodent and Nonhuman Primate. Fang, Fang; Zhang, Jie; Hu, Yang. Methods in Molecular Biology. 2023. 2708; 57-69.DOI: 10.1007/978-1-0716-3409-7_7. PMID: 37558960.
RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function. Fang, Fang; Liu, Pingting; Huang, Haoliang; Feng, Xue; Li, Liang; Sun, Yang; Kaufman, Randal J.; Hu, Yang. Molecular Therapy – Nucleic Acids. 2023. 33; 286-295.DOI: 10.1016/j.omtn.2023.07.015. PMID: 37547290.PMCID: PMC10400881.
The importance of unambiguous cell origin determination in neuronal repopulation studies. Johnson, Thomas V; Calkins, David J; Fortune, Brad; Goldberg, Jeffrey L; La Torre, Anna; Lamba, Deepak A; Meyer, Jason S; Reh, Thomas A; Wallace, Valerie A; Zack, Donald J; Baranov, Petr. iScience. 2023. 26(4); 106361.DOI: 10.1016/j.isci.2023.106361. PMID: 37009209. PMCID: PMC10060674.
Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies. Liu, Pingting; Chen, Wei; Jiang, Haowen; Huang, Haoliang; Liu, Liping; Fang, Fang; Li, Liang; Feng, Xue; Liu, Dong; Dalal, Roopa; Sun, Yang; Jafar-Nejad, Paymaan; Ling, Karen; Rigo, Frank; Ye, Jiangbin; Hu, Yang. Molecular Therapy – Nucleic Acids. 2023. 32(); 13-27.DOI: 10.1016/j.omtn.2023.02.029. PMID: 36950280. PMCID: PMC10025007.
Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques. Moshiri, Ala; Fang, Fang; Zhuang, Pei; Huang, Haoliang; Feng, Xue; Li, Liang; Dalal, Roopa; Hu, Yang. International Journal of Molecular Sciences. 2022. 23(24); 15896.DOI: 10.3390/ijms232415896. PMID: 36555536. PMCID: PMC9781764.
Longitudinal in vivo Ca2+ imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level. Li, Liang; Feng, Xue; Fang, Fang; Miller, David A.; Zhang, Shaobo; Zhuang, Pei; Huang, Haoliang; Liu, Pingting; Liu, Junting; Sredar, Nripun; Liu, Liang; Sun, Yang; Duan, Xin; Goldberg, Jeffrey L.; Zhang, Hao F.; Hu, Yang. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119(48); e2206829119.DOI: 10.1073/pnas.2206829119. PMID: 36409915.PMCID: PMC9889883.
Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. Chen, Wei; Liu, Pingting; Liu, Dong; Huang, Haoliang; Feng, Xue; Fang, Fang; Li, Liang; Wu, Jian; Liu, Liang; Solow-Cordero, David E.; Hu, Yang. Nature Communications. 2022. 13(1); 6796.DOI: 10.1038/s41467-022-34682-y. PMID: 36357388. PMCID: PMC9649812.
Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes. Li, Liang; Fang, Fang; Feng, Xue; Zhuang, Pei; Huang, Haoliang; Liu, Pingting; Liu, Liang; Xu, Adam Z; Qi, Lei S; Cong, Le; Hu, Yang. Neuron. 2022. 110(16); 2646-2663.e6.DOI: 10.1016/j.neuron.2022.06.022. PMID: 35952672. PMCID: PMC9391304
Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques. Moshiri, Ala; Fang, Fang; Zhuang, Pei; Huang, Haoliang; Feng, Xue; Li, Liang; Dalal, Roopa; Hu, Yang. International Journal of Molecular Sciences. 2022 Dec 14;23(24): 15896. doi: 10.3390/ijms232415896. PMID: 36555536. PMCID: PMC9781764
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin. Tsai, Nicole Y.; Wang, Fei; Toma, Kenichi; Yin, Chen; Takatoh, Jun; Pai, Emily L.; Wu, Kongyan; Matcham, Angela C.; Yin, Luping; Dang, Eric J.; Marciano, Denise K.; Rubenstein, John L.; Wang, Fan; Ullian, Erik M.; Duan, Xin. Nature Neuroscience. 2022. 25(5); 659-674.DOI: 10.1038/s41593-022-01068-8. PMID: 35524141.PMCID: PMC9172271.
Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells. Kowal, Tia J.; Dhande, Onkar S.; Wang, Biao; Wang, Qing; Ning, Ke; Liu, Wendy; Berbari, Nicolas F.; Hu, Yang; Sun, Yang. The Journal of Comparative Neurology. 2022. 530(12); 2176-2187.DOI: 10.1002/cne.25326. PMID: 35434813.PMCID: PMC9219574.
Solving neurodegeneration: common mechanisms and strategies for new treatments. Wareham, Lauren K.; Liddelow, Shane A.; Temple, Sally; Benowitz, Larry I.; Di Polo, Adriana; Wellington, Cheryl; Goldberg, Jeffrey L.; He, Zhigang; Duan, Xin; Bu, Guojun; Davis, Albert A.; Shekhar, Karthik; Torre, Anna La; Chan, David C.; Canto-Soler, M. Valeria; Flanagan, John G.; Subramanian, Preeti; Rossi, Sharyn; Brunner, Thomas; Bovenkamp, Diane E.; Calkins, David J.. Molecular Neurodegeneration. 2022. 17(1); 23.DOI: 10.1186/s13024-022-00524-0. PMID: 35313950. PMCID: PMC8935795.
Polymorphous low-grade adenocarcinoma with cavernous sinus involvement presenting as third nerve palsy. Chan, Alison X.; Chang, Aimee; L., Jiun; Koo, Sonya J.; Lin, Grace; Welsbie, Derek S. American Journal of Ophthalmology Case Reports. 2022. 26(); 101460.DOI: 10.1016/j.ajoc.2022.101460. PMID: 35313474. PMCID: PMC8933825.
NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function. Fang, Fang; Zhuang, Pei; Feng, Xue; Liu, Pingting; Liu, Dong; Huang, Haoliang; Li, Liang; Chen, Wei; Liu, Liang; Sun, Yang; Jiang, Haowen; Ye, Jiangbin; Hu, Yang. Molecular Therapy. 2022. 30(4); 1421-1431.DOI: 10.1016/j.ymthe.2022.01.035. PMID: 35114390. PMCID: PMC9077370.
Neuronal NMNAT2 Overexpression Does Not Achieve Significant Neuroprotection in Experimental Autoimmune Encephalomyelitis/Optic Neuritis. Liu, Pingting; Huang, Haoliang; Fang, Fang; Liu, Liang; Li, Liang; Feng, Xue; Chen, Wei; Dalal, Roopa; Sun, Yang; Hu, Yang. Frontiers in Cellular Neuroscience. 2021. 15; 754651.DOI: 10.3389/fncel.2021.754651. PMID: 34707482. PMCID: PMC8542903.
Optic Nerve Engraftment of Neural Stem Cells. L., Jiun; Allahwerdy, Salam; David, Ryan Caezar C.; Weinreb, Robert N.; Tuszynski, Mark H.; Welsbie, Derek S. Investigative Ophthalmology & Visual Science. 2021. 62(9); 30-30.DOI: 10.1167/iovs.62.9.30. PMID: 34283208. PMCID: PMC8300061.
OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. Wang, Biao; He, Wei; Prosseda, Philipp P; Li, Liang; Kowal, Tia J; Alvarado, Jorge A; Wang, Qing; Hu, Yang; Sun, Yang. EMBO Reports. 2021. 22(7); embr202052173.DOI: 10.15252/embr.202052173. PMID: 33987909. PMCID: PMC8406401.
Optogenetic Modulation of Intraocular Pressure in a Glucocorticoid-Induced Ocular Hypertension Mouse Model. Kowal, Tia J.; Prosseda, Philipp P.; Ning, Ke; Wang, Biao; Alvarado, Jorge; Sendayen, Brent E.; Jabbehdari, Sayena; Stamer, W. Daniel; Hu, Yang; Sun, Yang. Translational Vision Science & Technology. 2021. 10(6); 10-10.DOI: 10.1167/tvst.10.6.10. PMID: 34111256. PMCID: PMC8107493.
Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension. Fang, Fang; Zhang, Jie; Zhuang, Pei; Liu, Pingting; Li, Liang; Huang, Haoliang; Webber, Hannah C.; Xu, Yangfan; Liu, Liang; Dalal, Roopa; Sun, Yang; Hu, Yang. Scientific Reports. 2021. 11(1); 9052.DOI: 10.1038/s41598-021-88690-x. PMID: 33907301. PMCID: PMC8079709.
In vivo interactome profiling by enzyme‐catalyzed proximity labeling. Xu, Yangfan; Fan, Xianqun; Hu, Yang. Cell & Bioscience. 2021. 11(1); 27.DOI: 10.1186/s13578-021-00542-3. PMID: 33514425. PMCID: PMC7847152.
Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons. Patel, Amit K.; Broyer, Risa M.; Lee, Cassidy D.; Lu, Tianlun; Louie, Mikaela J.; La Torre, Anna; Al-Ali, Hassan; Vu, Mai T.; Mitchell, Katherine L.; Wahlin, Karl J.; Berlinicke, Cynthia A.; Jaskula-Ranga, Vinod; Hu, Yang; Duan, Xin; Vilar, Santiago; Bixby, John L.; Weinreb, Robert N.; Lemmon, Vance P.; Zack, Donald J.; Welsbie, Derek S. Proceedings of the National Academy of Sciences of the United States of America. 2020. 117(52); 33597-33607.DOI: 10.1073/pnas.2004683117. PMID: 33318207. PMCID: PMC7777023.
Longitudinal Morphological and Functional Assessment of RGC Neurodegeneration After Optic Nerve Crush in Mouse. Li, Liang; Huang, Haoliang; Fang, Fang; Liu, Liang; Sun, Yang; Hu, Yang. Frontiers in Cellular Neuroscience. 2020. 14(); 109.DOI: 10.3389/fncel.2020.00109. PMID: 32410964.PMCID: PMC7200994.
Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells. Wang, Qizhao; Zhuang, Pei; Huang, Haoliang; Li, Liang; Liu, Liang; Webber, Hannah C.; Dalal, Roopa; Siew, Leonard; Fligor, Clarisse M.; Chang, Kun-Che; Nahmou, Michael; Kreymerman, Alexander; Sun, Yang; Meyer, Jason S.; Goldberg, Jeffrey Louis; Hu, Yang. Journal of Neuroscience. 2020. 40(20); 3896-3914.DOI: 10.1523/jneurosci.0102-20.2020. PMID: 32300046. PMCID: PMC7219295.
A Novel Reporter Mouse Uncovers Endogenous Brn3b Expression. Miltner, Adam M.; Mercado-Ayon, Yesica; Cheema, Simranjeet K.; Zhang, Pengfei; Zawadzki, Robert J.; La Torre, Anna. International Journal of Molecular Sciences. 2019. 20(12); 2903.DOI: 10.3390/ijms20122903. PMID: 31197108.PMCID: PMC6627301.
Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. Zhang, Jie; Li, Liang; Huang, Haoliang; Fang, Fang; Webber, Hannah C; Zhuang, Pei; Liu, Liang; Dalal, Roopa; Tang, Peter H; Mahajan, Vinit B; Sun, Yang; Li, Shaohua; Zhang, Mingchang; Goldberg, Jeffrey L; Hu, Yang. eLife. 2019. 8(); e45881.DOI: 10.7554/elife.45881. PMID: 31090540. PMCID: PMC6533060.
The Catalyst for a Cure Biomarker team of scientists (CFC 2) received important peer acknowledgment in key science publications. The following list of publications and abstracts represents research results published since 2012.
Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration. Rao, Mishal; Luo, Ziming; Liu, Chia-Chun; Chen, Chi-Yu; Wang, Shining; Nahmou, Michael; Tanasa, Bogdan; Virmani, Aman; Byrne, Leah; Goldberg, Jeffrey L.; Sahel, José-Alain; Chang, Kun-Che. Acta Neuropathologica Communications. 2024. 12(1); 204. DOI: 10.1186/s40478-024-01917-6. PMID: 39734233. PMCID: PMC11684310.
Glaucoma classification through SSVEP derived ON- and OFF-pathway features. Scott, Martin T W; Xu, Hui; Yakovleva, Alexandra; Tibshirani, Robert; Goldberg, Jeffrey L; Norcia, Anthony M. medRxiv. 2024.08.22.24312443. DOI: 10.1101/2024.08.22.24312443. PMID: 39228700. PMCID: PMC11370506.
Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration. Liu, Dong; Webber, Hannah C; Bian, Fuyun; Xu, Yangfan; Prakash, Manjari; Feng, Xue; Yang, Ming; Yang, Hang; You, In-Jee; Li, Liang; Liu, Liping; Liu, Pingting; Huang, Haoliang; Chang, Chien-Yi; Liu, Liang; Shah, Sahil H; Torre, Anna La; Welsbie, Derek S; Sun, Yang; Duan, Xin; Goldberg, Jeffrey L.; Braun, Marcus; Lansky, Zdenek; Hu, Yang. bioRxiv. 2024.04.02.587832. DOI: 10.1101/2024.04.02.587832. PMID: 38617277. PMCID: PMC11014509.
Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles. Zhu, Ying; Garcia-Sanchez, Julian; Dalal, Roopa; Sun, Yang; Kapiloff, Michael S; Goldberg, Jeffrey L; Liu, Wendy W. Experimental Eye Research. 2023. 236(); 109675. DOI: 10.1016/j.exer.2023.109675. PMID: 37820892. PMCID: PMC10843266.
Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Soucy, Jonathan R.; Aguzzi, Erika A.; Cho, Julie; Gilhooley, Michael James; Keuthan, Casey; Luo, Ziming; Monavarfeshani, Aboozar; Saleem, Meher A.; Wang, Xue-Wei; Wohlschlegel, Juilette; Baranov, Petr; Di Polo, Adriana; Fortune, Brad; Gokoffski, Kimberly K.; Goldberg, Jeffrey L.; Guido, William; Kolodkin, Alex L.; Mason, Carol A.; Ou, Yvonne; Reh, Thomas A.; Ross, Ahmara G.; Samuels, Brian C.; Welsbie, Derek; Zack, Donald J.; Johnson, Thomas V. Molecular Neurodegeneration. 2023. 18(1); 64. DOI: 10.1186/s13024-023-00655-y. PMID: 37735444. PMCID: PMC10514988.
The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium. Johnson, Thomas V.; Baranov, Petr; Di Polo, Adriana; Fortune, Brad; Gokoffski, Kimberly K.; Goldberg, Jeffrey L.; Guido, William; Kolodkin, Alex L.; Mason, Carol A.; Ou, Yvonne; Reh, Thomas A.; Ross, Ahmara G.; Samuels, Brian C.; Zack, Donald J. Ophthalmology Science. 2023. 3(4); 100390. DOI: 10.1016/j.xops.2023.100390. PMID: 38025164. PMCID: PMC10630665.
Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation. Rao, Mishal; Huang, Yu-Kai; Liu, Chia-Chun; Meadows, Chandler; Cheng, Hui-Chun; Zhou, Mengli; Chen, Yu-Chih; Xia, Xin; Goldberg, Jeffrey L.; Williams, Andrew M.; Kuwajima, Takaaki; Chang, Kun-Che. Scientific Reports. 2023. 13(1); 5592. DOI: 10.1038/s41598-023-32702-5. PMID: 37019993. PMCID: PMC10076364.
The importance of unambiguous cell origin determination in neuronal repopulation studies. Johnson, Thomas V; Calkins, David J; Fortune, Brad; Goldberg, Jeffrey L; La Torre, Anna; Lamba, Deepak A; Meyer, Jason S; Reh, Thomas A; Wallace, Valerie A; Zack, Donald J; Baranov, Petr. iScience. 2023. 26(4); 106361. DOI: 10.1016/j.isci.2023.106361. PMID: 37009209. PMCID: PMC10060674.
Longitudinal in vivo Ca2+ imaging reveals dynamic activity changes of diseased retinal ganglion cells at the single-cell level. Li, Liang; Feng, Xue; Fang, Fang; Miller, David A.; Zhang, Shaobo; Zhuang, Pei; Huang, Haoliang; Liu, Pingting; Liu, Junting; Sredar, Nripun; Liu, Liang; Sun, Yang; Duan, Xin; Goldberg, Jeffrey L.; Zhang, Hao F.; Hu, Yang. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119(48); e2206829119. DOI: 10.1073/pnas.2206829119. PMID: 36409915. PMCID: PMC9889883.
Preferential Loss of Contrast Decrement Responses in Human Glaucoma. Norcia, Anthony M.; Yakovleva, Alexandra; Jehangir, Naz; Goldberg, Jeffrey L. Investigative Ophthalmology & Visual Science. 2022. 63(11); 16. DOI: 10.1167/iovs.63.11.16. PMID: 36264656. PMCID: PMC9587510.
Elk-1 regulates retinal ganglion cell axon regeneration after injury. Noro, Takahiko; Shah, Sahil H.; Yin, Yuqin; Kawaguchi, Riki; Yokota, Satoshi; Chang, Kun-Che; Madaan, Ankush; Sun, Catalina; Coppola, Giovanni; Geschwind, Daniel; Benowitz, Larry I.; Goldberg, Jeffrey L. Scientific Reports. 2022. 12(1); 17446. DOI: 10.1038/s41598-022-21767-3. PMID: 36261683. PMCID: PMC9581912.
Quantitative BONCAT Allows Identification of Newly Synthesized Proteins after Optic Nerve Injury. Shah, Sahil H.; Schiapparelli, Lucio M.; Yokota, Satoshi; Ma, Yuanhui; Xia, Xin; Shankar, Sahana; Saturday, Sarah; Nahmou, Michael; Sun, Catalina; Yates, John; Cline, Hollis T.; Goldberg, Jeffrey L. Journal of Neuroscience. 2022. 42(19); 4042-4052. DOI: 10.1523/jneurosci.3100-20.2022. PMID: 35396330. PMCID: PMC9097770.
Solving neurodegeneration: common mechanisms and strategies for new treatments. Wareham, Lauren K.; Liddelow, Shane A.; Temple, Sally; Benowitz, Larry I.; Di Polo, Adriana; Wellington, Cheryl; Goldberg, Jeffrey L.; He, Zhigang; Duan, Xin; Bu, Guojun; Davis, Albert A.; Shekhar, Karthik; Torre, Anna La; Chan, David C.; Canto-Soler, M. Valeria; Flanagan, John G.; Subramanian, Preeti; Rossi, Sharyn; Brunner, Thomas; Bovenkamp, Diane E.; Calkins, David J. Molecular Neurodegeneration. 2022. 17(1); 23. DOI: 10.1186/s13024-022-00524-0. PMID: 35313950. PMCID: PMC8935795.
Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration. Shah, Sahil H; Schiapparelli, Lucio M; Ma, Yuanhui; Yokota, Satoshi; Atkins, Melissa; Xia, Xin; Cameron, Evan G; Huang, Thanh; Saturday, Sarah; Sun, Catalina B; Knasel, Cara; Blackshaw, Seth; Yates, John R; Cline, Hollis T; Goldberg, Jeffrey L. eLife. 2022. 11(); e68148. DOI: 10.7554/elife.68148. PMID: 35259089. PMCID: PMC8947766.
Artificial Intelligence for Glaucoma Creating and Implementing Artificial Intelligence for Disease Detection and Progression. Al-Aswad, A.; Ramachandran, Rithambara; Schuman, Joel S.; Medeiros, Felipe; Eydelman, Malvina B.; Workgroup, Collaborative Community for Ophthalmic Imaging Executive Committee and Glaucoma; Abramoff, Michael D.; Antony, Bhavna J.; Boland, Michael V.; Chauhan, Balwantray C.; Chiang, Michael; Goldberg, Jeffrey L.; Hammel, Naama; Pasquale, Louis R.; Quigley, Harry A.; Susanna, Remo; Vianna, Jayme; Zangwill, Linda. Ophthalmology Glaucoma. 2022. 5(5); e16-e25. DOI: 10.1016/j.ogla.2022.02.010. PMID: 35218987. PMCID: PMC9399304.
In-vivo sub-diffraction adaptive optics imaging of photoreceptors in the human eye with annular pupil illumination and sub-Airy detection. Lu, Rongwen; Aguilera, Nancy; Liu, Tao; Liu, Jianfei; Giannini, John P; Li, Joanne; Bower, Andrew J; Dubra, Alfredo; Tam, Johnny. Optica. 2021. 8(3); 333-343. DOI: 10.1364/optica.414206. PMID: 34504903. PMCID: PMC8425240.
Incoherent excess noise spectrally encodes broadband light sources. Kho, Aaron M.; Zhang, Tingwei; Zhu, Jun; Merkle, Conrad W.; Srinivasan, Vivek J. Light: Science & Applications. 2020. 9(1); 172. DOI: 10.1038/s41377-020-00404-6. PMID: 33082941. PMCID: PMC7538909.
Dynamics of Contrast Decrement and Increment Responses in Human Visual Cortex. Norcia, Anthony M.; Yakovleva, Alexandra; Hung, Bethany; Goldberg, Jeffrey L. Translational Vision Science & Technology. 2020. 9(10); 6-6. DOI: 10.1167/tvst.9.10.6. PMID: 32953246. PMCID: PMC7476656.
Visibility of microvessels in Optical Coherence Tomography angiography depends on angular orientation. Zhu, Jun; Bernucci, Marcel T.; Merkle, Conrad W.; Srinivasan, Vivek J. Journal of Biophotonics. 2020. 13(10); e202000090. DOI: 10.1002/jbio.202000090. PMID: 32468737. PMCID: PMC7737355.
Discovery and clinical translation of novel glaucoma biomarkers. Beykin, Gala; Norcia, Anthony M; Srinivasan, Vivek J; Dubra, Alfredo; Goldberg, Jeffrey L. Progress in Retinal and Eye Research. 2020. 80(); 100875. DOI: 10.1016/j.preteyeres.2020.100875. PMID: 32659431. PMCID: PMC7796965.
Imaging oxygenation of retinal capillaries with depth resolution. Srinivasan, Vivek J.; Moshiri, Ala. Proceedings of the National Academy of Sciences of the United States of America. 2020. 117(26); 14626-14628. DOI: 10.1073/pnas.2008404117. PMID: 32554605. PMCID: PMC7334518.
Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells. Wang, Qizhao; Zhuang, Pei; Huang, Haoliang; Li, Liang; Liu, Liang; Webber, Hannah C.; Dalal, Roopa; Siew, Leonard; Fligor, Clarisse M.; Chang, Kun-Che; Nahmou, Michael; Kreymerman, Alexander; Sun, Yang; Meyer, Jason S.; Goldberg, Jeffrey L.; Hu, Yang. Journal of Neuroscience. 2020. 40(20); 3896-3914. DOI: 10.1523/jneurosci.0102-20.2020. PMID: 32300046. PMCID: PMC7219295.
Dynamic Contrast Optical Coherence Tomography reveals laminar microvascular hemodynamics in the mouse neocortex in vivo. Merkle, Conrad W; Zhu, Jun; Bernucci, Marcel T; Srinivasan, Vivek J. NeuroImage. 2019. 202; 116067. DOI: 10.1016/j.neuroimage.2019.116067. PMID: 31394180. PMCID: PMC6819266.
The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo. Schiapparelli, Lucio M.; Shah, Sahil H.; Ma, Yuanhui; McClatchy, Daniel B.; Sharma, Pranav; Li, Jianli; Yates, John R.; Goldberg, Jeffrey L.; Cline, Hollis T. Cell Reports. 2019. 28(7); 1935-1947.e5. DOI: 10.1016/j.celrep.2019.07.037. PMID: 31412257. PMCID: PMC6707540.
Molecular Biomarkers for Glaucoma. Beykin, Gala; Goldberg, Jeffrey L. Current Ophthalmology Reports. 2019. 7(3); 171-176. DOI: 10.1007/s40135-019-00213-0. PMID: 33133776. PMCID: PMC7597904.
Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation. Weiner, G. A.; Shah, S. H.; Angelopoulos, C. M.; Bartakova, A. B.; Pulido, R. S.; Murphy, A.; Nudleman, E.; Daneman, R.; Goldberg, J. L. Nature Communications. 2019. 10(1); 2477. DOI: 10.1038/s41467-019-10219-8. PMID: 31171770. PMCID: PMC6554348.
Improving visible light OCT of the human retina with rapid spectral shaping and axial tracking. Zhang, Tingwei; Kho, Aaron M; Srinivasan, Vivek J. Biomedical Optics Express. 2019. 10(6); 2918-2931. DOI: 10.1364/boe.10.002918. PMID: 31259062. PMCID: PMC6583340.
Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse. Zhang, Jie; Li, Liang; Huang, Haoliang; Fang, Fang; Webber, Hannah C; Zhuang, Pei; Liu, Liang; Dalal, Roopa; Tang, Peter H; Mahajan, Vinit B; Sun, Yang; Li, Shaohua; Zhang, Mingchang; Goldberg, Jeffrey L; Hu, Yang. eLife. 2019. 8(); e45881. DOI: 10.7554/elife.45881. PMID: 31090540. PMCID: PMC6533060.
Silicone Oil-Induced Ocular Hypertension in Mouse Models Glaucomatous Neurodegeneration and Neuroprotection. Zhang, Jie; Li, Liang; Huang, Haoliang; Webber, Hannah C.; Zhuang, Pei; Liu, Liang; Dalal, Roopa; Tang, Peter H.; Mahajan, Vinit B.; Sun, Yang; Li, Shaohua; Zhang, Mingchang; Goldberg, Jeffrey L; Hu, Yang. bioRxiv. 2019; 547661. DOI: 10.1101/547661.
Compensating spatially dependent dispersion in visible light OCT. Kho, Aaron; Srinivasan, Vivek J. Optics Letters. 2019. 44(4); 775-778. DOI: 10.1364/ol.44.000775. PMID: 30767984. PMCID: PMC6503663.
Sub‐topographic maps for regionally enhanced analysis of visual space in the mouse retina. El‐Danaf, Rana N.; Huberman, Andrew D. The Journal of Comparative Neurology. 2018. 527(1); 259-269. DOI: 10.1002/cne.24457. PMID: 29675855. PMCID: PMC6506235.
Long eye relief fundus camera and fixation target with partial correction of ocular longitudinal chromatic aberration. Steven, Samuel; Sulai, Yusufu N; Cheong, Soon K; Bentley, Julie; Dubra, Alfredo. Biomedical Optics Express. 2018. 9(12); 6017-6037. DOI: 10.1364/boe.9.006017. PMID: 31065410. PMCID: PMC6491002.
Assembly and repair of eye-to-brain connections. Varadarajan, Supraja G; Huberman, Andrew D. Current Opinion in Neurobiology. 2018. 53; 198-209. DOI: 10.1016/j.conb.2018.10.001. PMID: 30339988. PMCID: PMC6504177.
Dynamics of contrast decrement and increment responses in human visual cortex. Norcia, Anthony M.; Yakovleva, Alexandra; Hung, Bethany; Goldberg, Jeffrey L. bioRxiv. 2018; 425173. DOI: 10.1101/425173.
Cone Photoreceptor Cell Segmentation and Diameter Measurement on Adaptive Optics Images Using Circularly Constrained Active Contour Model. Liu, Jianfei; Jung, HaeWon; Dubra, Alfredo; Tam, Johnny. Investigative Ophthalmology & Visual Science. 2018. 59(11); 4639-4652. DOI: 10.1167/iovs.18-24734. PMID: 30372733. PMCID: PMC6154284.
Sub-Airy Confocal Adaptive Optics Scanning Ophthalmoscopy. Sredar, Nripun; Fagbemi, Oladipo E.; Dubra, Alfredo. Translational Vision Science & Technology. 2018. 7(2); 17-17. DOI: 10.1167/tvst.7.2.17. PMID: 29629239. PMCID: PMC5886094.
Erratum: Non-invasive assessment of human cone photoreceptor function: erratum. Cooper, Robert F; Tuten, William S; Dubra, Alfredo; Brainard, David H; Morgan, Jessica I W. Biomedical Optics Express. 2018. 9(4); 1842. DOI: 10.1364/boe.9.001842. PMID: 29676401. PMCID: PMC5905927.
Ultrahigh resolution retinal imaging by visible light OCT with longitudinal achromatization. Chong, Shau Poh; Zhang, Tingwei; Kho, Aaron; Bernucci, Marcel T; Dubra, Alfredo; Srinivasan, Vivek J. Biomedical Optics Express. 2018. 9(4); 1477-1491. DOI: 10.1364/boe.9.001477. PMID: 29675296. PMCID: PMC5905900.
Investigation of artifacts in retinal and choroidal OCT angiography with a contrast agent. Bernucci, Marcel T; Merkle, Conrad W; Srinivasan, Vivek J. Biomedical Optics Express. 2018. 9(3); 1020-1040. DOI: 10.1364/boe.9.001020. PMID: 29541501. PMCID: PMC5846511.
Visible light optical coherence microscopy of the brain with isotropic femtoliter resolution in vivo. Merkle, Conrad William; Chong, Shau Poh; Kho, Aaron Michael; Zhu, Jun; Dubra, Alfredo; Srinivasan, Vivek Jay. Optics Letters. 2018. 43(2); 198-201. DOI: 10.1364/ol.43.000198. PMID: 29328237. PMCID: PMC5953552.
Non-invasive assessment of human cone photoreceptor function. Cooper, Robert F; Tuten, William S; Dubra, Alfredo; Brainard, David H; Morgan, Jessica I W. Biomedical Optics Express. 2017. 8(11); 5098-5112. DOI: 10.1364/boe.8.005098. PMID: 29188106. PMCID: PMC5695956.
Automated Photoreceptor Cell Identification on Nonconfocal Adaptive Optics Images Using Multiscale Circular Voting. Liu, Jianfei; Jung, HaeWon; Dubra, Alfredo; Tam, Johnny. Investigative Ophthalmology & Visual Science. 2017. 58(11); 4477-4489. DOI: 10.1167/iovs.16-21003. PMID: 28873173. PMCID: PMC5586244.
Progression of Local Glaucomatous Damage Near Fixation as Seen with Adaptive Optics ImagingHood et al. Hood, Donald C.; Lee, Dongwon; Jarukasetphon, Ravivarn; Nunez, Jason; Mavrommatis, Maria A.; Rosen, Richard B.; Ritch, Robert; Dubra, Alfredo; Chui, Toco Y. P. Translational Vision Science & Technology. 2017. 6(4); 6-6. DOI: 10.1167/tvst.6.4.6. PMID: 28713646. PMCID: PMC5508541.
Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?. Zhu, Jun; Merkle, Conrad W.; Bernucci, Marcel T.; Chong, Shau Poh; Srinivasan, Vivek J. Applied Sciences. 2017. 7(7); 687. DOI: 10.3390/app7070687. PMID: 30009045. PMCID: PMC6042878.
Regenerating optic pathways from the eye to the brain. Laha, Bireswar; Stafford, Ben K; Huberman, Andrew D. Science. 2017. 356(6342); 1031-1034. DOI: 10.1126/science.aal5060. PMID: 28596336. PMCID: PMC6333302.
PHOTORECEPTOR INNER SEGMENT MORPHOLOGY IN BEST VITELLIFORM MACULAR DYSTROPHY. Scoles, Drew; Sulai, Yusufu N.; Cooper, Robert F.; Higgins, Brian P.; Johnson, Ryan D.; Carroll, Joseph; Dubra, Alfredo; Stepien, Kimberly E. Retina. 2017. 37(4); 741-748. DOI: 10.1097/iae.0000000000001203. PMID: 27467379. PMCID: PMC5362286.
Structural and functional human retinal imaging with a fiber-based visible light OCT ophthalmoscope. Chong, Shau Poh; Bernucci, Marcel; Radhakrishnan, Harsha; Srinivasan, Vivek J. Biomedical Optics Express. 2016. 8(1); 323-337. DOI: 10.1364/boe.8.000323. PMID: 28101421. PMCID: PMC5231302.
Noninvasive imaging of the photoreceptor mosaic response to light stimulation. Srinivasan, Vivek J.; Dubra, Alfredo. Proceedings of the National Academy of Sciences of the United States of America. 2016. 113(46); 12902-12903. DOI: 10.1073/pnas.1615790113. PMID: 27810954. PMCID: PMC5135298.
Dynamic contrast optical coherence tomography images transit time and quantifies microvascular plasma volume and flow in the retina and choriocapillaris. Merkle, Conrad W; Leahy, Conor; Srinivasan, Vivek J. Biomedical Optics Express. 2016. 7(10); 4289-4312. DOI: 10.1364/boe.7.004289. PMID: 27867732. PMCID: PMC5102529.
Microstructural characterization of myocardial infarction with optical coherence tractography and two‐photon microscopy. Goergen, Craig J.; Chen, Howard H.; Sakadžić, Sava; Srinivasan, Vivek J.; Sosnovik, David E. Physiological Reports. 2016. 4(18); e12894. DOI: 10.14814/phy2.12894. PMID: 27650248. PMCID: PMC5037910.
In Vivo Imaging of the Human Retinal Pigment Epithelial Mosaic Using Adaptive Optics Enhanced Indocyanine Green Ophthalmoscopy. Tam, Johnny; Liu, Jianfei; Dubra, Alfredo; Fariss, Robert. Investigative Ophthalmology & Visual Science. 2016. 57(10); 4376-4384. DOI: 10.1167/iovs.16-19503. PMID: 27564519. PMCID: PMC5015921.
Neural activity promotes long-distance, target-specific regeneration of adult retinal axons. Lim, Jung-Hwan A; Stafford, Benjamin K; Nguyen, Phong L; Lien, Brian V; Wang, Chen; Zukor, Katherine; He, Zhigang; Huberman, Andrew D. Nature Neuroscience. 2016. 19(8); 1073-1084. DOI: 10.1038/nn.4340. PMID: 27399843. PMCID: PMC5708130.
Imaging Foveal Microvasculature: Optical Coherence Tomography Angiography Versus Adaptive Optics Scanning Light Ophthalmoscope Fluorescein AngiographyImaging Foveal Microvasculature: OCTA Versus AOSLO FA. Mo, Shelley; Krawitz, Brian; Efstathiadis, Eleni; Geyman, Lawrence; Weitz, Rishard; Chui, Toco Y. P.; Carroll, Joseph; Dubra, Alfredo; Rosen, Richard B. Investigative Ophthalmology & Visual Science. 2016. 57(9); oct130-oct140. DOI: 10.1167/iovs.15-18932. PMID: 27409463. PMCID: PMC4968918.
Noninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic. Sajdak, Benjamin; Sulai, Yusufu N.; Langlo, Christopher S.; Luna, Gabriel; Fisher, Steven K.; Merriman, Dana K.; Dubra, Alfredo. Visual Neuroscience. 2016. 33(); e003. DOI: 10.1017/s0952523815000346. PMID: 26923645. PMCID: PMC4793898.
Longitudinal imaging of microvascular remodelling in proliferative diabetic retinopathy using adaptive optics scanning light ophthalmoscopy. Chui, Toco Yuen Ping; Pinhas, Alexander; Gan, Alexander; Razeen, Moataz; Shah, Nishit; Cheang, Eric; Liu, Chun L; Dubra, Alfredo; Rosen, Richard B. Ophthalmic & Physiological Optics. 2016. 36(3); 290-302. DOI: 10.1111/opo.12273. PMID: 26803289. PMCID: PMC4846498.
Contributions of Retinal Ganglion Cells to Subcortical Visual Processing and Behaviors. Dhande, Onkar S; Stafford, Benjamin K; Lim, Jung-Hwan A; Huberman, Andrew D. Annual Review of Vision Science. 2015. 1(1); 291-328. DOI: 10.1146/annurev-vision-082114-035502. PMID: 28532372.
Laminar microvascular transit time distribution in the mouse somatosensory cortex revealed by Dynamic Contrast Optical Coherence Tomography. Merkle, Conrad W.; Srinivasan, Vivek J. NeuroImage. 2015. 125(); 350-362. DOI: 10.1016/j.neuroimage.2015.10.017. PMID: 26477654. PMCID: PMC4691378.
Cerebral metabolic rate of oxygen (CMRO<sub>2</sub>) assessed by combined Doppler and spectroscopic OCT. Chong, Shau Poh; Merkle, Conrad W.; Leahy, Conor; Srinivasan, Vivek J. Biomedical Optics Express. 2015. 6(10); 3941-3951. DOI: 10.1364/boe.6.003941. PMID: 26504644. PMCID: PMC4605053.
Cell type–specific manipulation with GFP-dependent Cre recombinase. Tang, Jonathan C Y; Rudolph, Stephanie; Dhande, Onkar S; Abraira, Victoria E; Choi, Seungwon; Lapan, Sylvain W; Drew, Iain R; Drokhlyansky, Eugene; Huberman, Andrew D; Regehr, Wade G; Cepko, Constance L. Nature Neuroscience. 2015. 18(9); 1334-1341. DOI: 10.1038/nn.4081. PMID: 26258682. PMCID: PMC4839275.
Micro-Heterogeneity of Flow in a Mouse Model of Chronic Cerebral Hypoperfusion Revealed by Longitudinal Doppler Optical Coherence Tomography and Angiography. Srinivasan, Vivek J; Yu, Esther; Radhakrishnan, Harsha; Can, Anil; Climov, Mihail; Leahy, Conor; Ayata, Cenk; Eikermann-Haerter, Katharina. Cerebrovascular and Brain Metabolism Reviews. 2015. 35(10); 1552-1560. DOI: 10.1038/jcbfm.2015.175. PMID: 26243708. PMCID: PMC4640323.
Quantitative microvascular hemoglobin mapping using visible light spectroscopic Optical Coherence Tomography. Chong, Shau Poh; Merkle, Conrad W; Leahy, Conor; Radhakrishnan, Harsha; Srinivasan, Vivek J. Biomedical Optics Express. 2015. 6(4); 1429-1450. DOI: 10.1364/boe.6.001429. PMID: 25909026. PMCID: PMC4399681.
Characteristic Patterns of Dendritic Remodeling in Early-Stage Glaucoma: Evidence from Genetically Identified Retinal Ganglion Cell Types. El-Danaf, Rana N.; Huberman, Andrew D. Journal of Neuroscience. 2015. 35(6); 2329-2343. DOI: 10.1523/jneurosci.1419-14.2015. PMID: 25673829. PMCID: PMC6605614.
Non-common path aberration correction in an adaptive optics scanning ophthalmoscope. Sulai, Yusufu N; Dubra, Alfredo. Biomedical Optics Express. 2014. 5(9); 3059-73. DOI: 10.1364/boe.5.003059. PMID: 25401020. PMCID: PMC4230870.
Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation. Srinivasan, Vivek J.; Radhakrishnan, Harsha. NeuroImage. 2014. 102(0 2); 393-406. DOI: 10.1016/j.neuroimage.2014.08.004. PMID: 25111471. PMCID: PMC4253684.
Comparison of adaptive optics scanning light ophthalmoscopic fluorescein angiography and offset pinhole imaging. Chui, Toco Y P; Dubow, Michael; Pinhas, Alexander; Shah, Nishit; Gan, Alexander; Weitz, Rishard; Sulai, Yusufu N; Dubra, Alfredo; Rosen, Richard B. Biomedical Optics Express. 2014. 5(4); 1173-89. DOI: 10.1364/boe.5.001173. PMID: 24761299. PMCID: PMC3985984.
Maximum Likelihood Doppler Frequency Estimation Under Decorrelation Noise for Quantifying Flow in Optical Coherence Tomography. Chan, Aaron C.; Srinivasan, Vivek J. *; Lam, Edmund Y. IEEE Transactions on Medical Imaging. 2014. 33(6); 1313-1323. DOI: 10.1109/tmi.2014.2309986. PMID: 24760902.
Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope. Sulai, Yusufu N.; Scoles, Drew; Harvey, Zachary; Dubra, Alfredo. Journal of the Optical Society of America A. 2014. 31(3); 569-79. DOI: 10.1364/josaa.31.000569. PMID: 24690655. PMCID: PMC4465430.
Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. Triplett, Jason W; Wei, Wei; Gonzalez, Cristina; Sweeney, Neal T; Huberman, Andrew D; Feller, Marla B; Feldheim, David A. Neural Development. 2014. 9(1); 2. DOI: 10.1186/1749-8104-9-2. PMID: 24495295. PMCID: PMC3937143.
Genetic Dissection of Retinal Inputs to Brainstem Nuclei Controlling Image Stabilization. Dhande, Onkar S.; Estevez, Maureen E.; Quattrochi, Lauren E.; El-Danaf, Rana N.; Nguyen, Phong L.; Berson, David M.; Huberman, Andrew D. Journal of Neuroscience. 2013. 33(45); 17797-17813. DOI: 10.1523/jneurosci.2778-13.2013. PMID: 24198370. PMCID: PMC3818553.
Volumetric imaging and quantification of cytoarchitecture and myeloarchitecture with intrinsic scattering contrast. Leahy, Conor; Radhakrishnan, Harsha; Srinivasan, Vivek J. Biomedical Optics Express. 2013. 4(10); 1978-90. DOI: 10.1364/boe.4.001978. PMID: 24156058. PMCID: PMC3799660.
Multiparametric, Longitudinal Optical Coherence Tomography Imaging Reveals Acute Injury and Chronic Recovery in Experimental Ischemic Stroke. Srinivasan, Vivek J.; Mandeville, Emiri T.; Can, Anil; Blasi, Francesco; Climov, Mihail; Daneshmand, Ali; Lee, Jeong Hyun; Yu, Esther; Radhakrishnan, Harsha; Lo, Eng H.; Sakadžić, Sava; Eikermann-Haerter, Katharina; Ayata, Cenk. PLOS ONE. 2013. 8(8); e71478. DOI: 10.1371/journal.pone.0071478. PMID: 23940761. PMCID: PMC3737090.
In vivo imaging of human retinal microvasculature using adaptive optics scanning light ophthalmoscope fluorescein angiography. Pinhas, Alexander; Dubow, Michael; Shah, Nishit; Chui, Toco Y.; Scoles, Drew; Sulai, Yusufu N.; Weitz, Rishard; Walsh, Joseph B.; Carroll, Joseph; Dubra, Alfredo; Rosen, Richard B. Biomedical Optics Express. 2013. 4(8); 1305-1317. DOI: 10.1364/boe.4.001305. PMID: 24009994. PMCID: PMC3756583.
Comparison of Kasai Autocorrelation and Maximum Likelihood Estimators for Doppler Optical Coherence Tomography. Chan, Aaron C.; Lam, Edmund Y.; Srinivasan, Vivek J. IEEE Transactions on Medical Imaging. 2013. 32(6); 1033-1042. DOI: 10.1109/tmi.2013.2248163. PMID: 23446044. PMCID: PMC3745780.
Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry. Beier, Kevin T.; Borghuis, Bart G.; El-Danaf, Rana N.; Huberman, Andrew D.; Demb, Jonathan B.; Cepko, Constance L. Journal of Neuroscience. 2013. 33(1); 35-51. DOI: 10.1523/jneurosci.0245-12.2013. PMID: 23283320. PMCID: PMC3711516.
Optimal Doppler Frequency Estimators for Ultrasound and Optical Coherence Tomography. Chan, Aaron C.; Lam, Edmund Y.; Srinivasan, Vivek J. 2012; 264-267. DOI: 10.1109/biocas.2012.6418446.
Optical coherence tractography using intrinsic contrast. Goergen, Craig J; Radhakrishnan, Harsha; Sakadžić, Sava; Mandeville, Emiri T; Lo, Eng H; Sosnovik, David E; Srinivasan, Vivek J. Optics Letters. 2012. 37(18); 3882-4. DOI: 10.1364/ol.37.003882. PMID: 23041891. PMCID: PMC3691965.
OCT methods for capillary velocimetry. Srinivasan, Vivek J.; Radhakrishnan, Harsha; Lo, Eng H.; Mandeville, Emiri T.; Jiang, James Y.; Barry, Scott; Cable, Alex E. Biomedical Optics Express. 2012. 3(3); 612-629. DOI: 10.1364/boe.3.000612. PMID: 22435106. PMCID: PMC3296546.
Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast. Srinivasan, Vivek J.; Radhakrishnan, Harsha; Jiang, James Y.; Barry, Scott; Cable, Alex E. Optics Express. 2012. 20(3); 2220-2239. DOI: 10.1364/oe.20.002220. PMID: 22330462. PMCID: PMC3306182.
The initial team of Catalyst for a Cure research scientists achieved important peer acknowledgment in key science publications. The following list of publications and abstracts represents research results published since 2006.
Beyond hypertrophy: Changing views of astrocytes in glaucoma. Cooper, Melissa L; Calkins, David J. Vision Research. 2024. 223(); 108461. DOI: 10.1016/j.visres.2024.108461. PMID: 39059109.
Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments. Bou Ghanem, Ghazi O; Wareham, Lauren K; Calkins, David J. Progress in Retinal and Eye Research. 2024. 100(); 101261. DOI: 10.1016/j.preteyeres.2024.101261. PMID: 38527623.
The importance of unambiguous cell origin determination in neuronal repopulation studies. Johnson, Thomas V; Calkins, David J; Fortune, Brad; Goldberg, Jeffrey L; La Torre, Anna; Lamba, Deepak A; Meyer, Jason S; Reh, Thomas A; Wallace, Valerie A; Zack, Donald J; Baranov, Petr. iScience. 2023. 26(4); 106361. DOI: 10.1016/j.isci.2023.106361. PMID: 37009209. PMCID: PMC10060674.
Solving neurodegeneration: common mechanisms and strategies for new treatments. Wareham, Lauren K.; Liddelow, Shane A.; Temple, Sally; Benowitz, Larry I.; Di Polo, Adriana; Wellington, Cheryl; Goldberg, Jeffrey L.; He, Zhigang; Duan, Xin; Bu, Guojun; Davis, Albert A.; Shekhar, Karthik; Torre, Anna La; Chan, David C.; Canto-Soler, M. Valeria; Flanagan, John G.; Subramanian, Preeti; Rossi, Sharyn; Brunner, Thomas; Bovenkamp, Diane E.; Calkins, David J. Molecular Neurodegeneration. 2022. 17(1); 23. DOI: 10.1186/s13024-022-00524-0. PMID: 35313950. PMCID: PMC8935795.
Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice. Holden, Joseph M; Al Hussein Al Awamlh, Sara; Croteau, Louis-Philippe; Boal, Andrew M; Rex, Tonia S; Risner, Michael L; Calkins, David J; Wareham, Lauren K. International Journal of Molecular Sciences. 2022. 23(6); 3066. DOI: 10.3390/ijms23063066. PMID: 35328488. PMCID: PMC8954518.
Adaptive responses to neurodegenerative stress in glaucoma. Calkins, David J. Progress in Retinal and Eye Research. 2021. 84(); 100953. DOI: 10.1016/j.preteyeres.2021.100953. PMID: 33640464. PMCID: PMC8384979.
Protect, Repair, and Regenerate: Towards Restoring Vision in Glaucoma. Wareham, Lauren K.; Risner, Michael L.; Calkins, David J. Current Ophthalmology Reports. 2020. 8(4); 301-310. DOI: 10.1007/s40135-020-00259-5. PMID: 33269115. PMCID: PMC7686214.
The Neurovascular Unit in Glaucomatous Neurodegeneration. Wareham, Lauren K.; Calkins, David J. Frontiers in Cell and Developmental Biology. 2020. 8(); 452. DOI: 10.3389/fcell.2020.00452. PMID: 32656207. PMCID: PMC7325980.
Of Mice and Monkeys: Neuroprotective Efficacy of the p38 Inhibitor BIRB 796 Depends on Model Duration in Experimental Glaucoma. Lambert, Wendi S.; Pasini, Silvia; Collyer, John W.; Formichella, Cathryn R.; Ghose, Purnima; Carlson, Brian J.; Calkins, David J. Scientific Reports. 2020. 10(1); 8535. DOI: 10.1038/s41598-020-65374-6. PMID: 32444682. PMCID: PMC7244559.
Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate. Lambert, Wendi S.; Carlson, Brian J.; Ghose, Purnima; Vest, Victoria D.; Yao, Vincent; Calkins, David J. Scientific Reports. 2019. 9(1); 11572. DOI: 10.1038/s41598-019-48054-y. PMID: 31399621. PMCID: PMC6689098.
Progression and Pathology of Traumatic Optic Neuropathy From Repeated Primary Blast Exposure. Bernardo-Colón, Alexandra; Vest, Victoria; Cooper, Melissa L.; Naguib, Sarah A.; Calkins, David J.; Rex, Tonia S. Frontiers in Neuroscience. 2019. 13(); 719. DOI: 10.3389/fnins.2019.00719. PMID: 31354422. PMCID: PMC6637732.
Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Bernardo-Colón, Alexandra; Vest, Victoria; Clark, Adrienne; Cooper, Melissa L.; Calkins, David J.; Harrison, Fiona E.; Rex, Tonia S. Cell Death & Disease. 2018. 9(11); 1097. DOI: 10.1038/s41419-018-1061-4. PMID: 30367086. PMCID: PMC6203845.
Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma. Bosco, Alejandra; Anderson, Sarah R; Breen, Kevin T; Romero, Cesar O; Steele, Michael R; Chiodo, Vince A; Boye, Sanford L; Hauswirth, William W; Tomlinson, Stephen; Vetter, Monica L. Molecular Therapy. 2018. 26(10); 2379-2396. DOI: 10.1016/j.ymthe.2018.08.017. PMID: 30217731. PMCID: PMC6171099.
Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma. Bosco, Alejandra; Anderson, Sarah R; Breen, Kevin T; Romero, Cesar O; Steele, Michael R; Chiodo, Vince A; Boye, Sanford L; Hauswirth, William W; Tomlinson, Stephen; Vetter, Monica L. bioRxiv. 2018; 369181. DOI: 10.1101/369181.
Astrocyte remodeling without gliosis precedes optic nerve axonopathy. Cooper, Melissa L.; Collyer, John W.; Calkins, David J. Acta Neuropathologica Communications. 2018. 6(1); 38. DOI: 10.1186/s40478-018-0542-0. PMID: 29747701. PMCID: PMC5946396.
Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma. Risner, Michael L.; Pasini, Silvia; Cooper, Melissa L.; Lambert, Wendi S.; Calkins, David J. Proceedings of the National Academy of Sciences of the United States of America. 2018. 115(10); e2393-e2402. DOI: 10.1073/pnas.1714888115. PMID: 29463759. PMCID: PMC5877940.
Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression. Nivison, Mary P.; Ericson, Nolan G.; Green, Virginia M.; Bielas, Jason H.; Campbell, Jean S.; Horner, Philip J. Experimental Neurology. 2017. 296(); 49-61. DOI: 10.1016/j.expneurol.2017.07.001. PMID: 28684211. PMCID: PMC6021128.
Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Breen, Kevin T.; Anderson, Sarah R.; Steele, Michael R.; Calkins, David J.; Bosco, Alejandra; Vetter, Monica L. Frontiers in Neuroscience. 2016. 10; 526. DOI: 10.3389/fnins.2016.00526. PMID: 27932942. PMCID: PMC5123443.
Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis. Whitworth, G.B.; Misaghi, B.C.; Rosenthal, D.M.; Mills, E.A.; Heinen, D.J.; Watson, A.H.; Ives, C.W.; Ali, S.H.; Bezold, K.; Marsh-Armstrong, N.; Watson, F.L. Developmental Biology. 2016. 426(2); 360-373. DOI: 10.1016/j.ydbio.2016.06.003. PMID: 27471010. PMCID: PMC5897040.
Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Bosco, Alejandra; Breen, Kevin T.; Anderson, Sarah R.; Steele, Michael R.; Calkins, David J.; Vetter, Monica L. Experimental Eye Research. 2016. 150(); 34-43. DOI: 10.1016/j.exer.2016.01.014. PMID: 26851485. PMCID: PMC4972706.
Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Cooper, Melissa L.; Crish, Samuel D.; Inman, Denise M.; Horner, Philip J.; Calkins, David J. Experimental Eye Research. 2015. 150(); 22-33. DOI: 10.1016/j.exer.2015.11.016. PMID: 26646560. PMCID: PMC4889569.
Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma. Bond, Wesley S; Hines-Beard, Jessica; GoldenMerry, YPaul L; Davis, Mara; Farooque, Alma; Sappington, Rebecca M; Calkins, David J; Rex, Tonia S. Molecular Therapy. 2015. 24(2); 230-239. DOI: 10.1038/mt.2015.198. PMID: 26502777. PMCID: PMC4817814.
Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis. Mills, Elizabeth A.; Davis, Chung-ha O.; Bushong, Eric A.; Boassa, Daniela; Kim, Keun-Young; Ellisman, Mark H.; Marsh-Armstrong, Nicholas. Proceedings of the National Academy of Sciences of the United States of America. 2015. 112(33); 10509-10514. DOI: 10.1073/pnas.1506486112. PMID: 26240339. PMCID: PMC4547286.
Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma. Bosco, Alejandra; Romero, Cesar O.; Breen, Kevin T.; Chagovetz, Alexis A.; Steele, Michael R.; Ambati, Balamurali K.; Vetter, Monica L. Disease Models & Mechanisms. 2015. 8(5); 443-455. DOI: 10.1242/dmm.018788. PMID: 25755083. PMCID: PMC4415894.
Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress. Sappington, Rebecca M; Sidorova, Tatiana; Ward, Nicholas J; Chakravarthy, Rohini; Ho, Karen W; Calkins, David J. Channels. 2015. 9(2); 102-113. DOI: 10.1080/19336950.2015.1009272. PMID: 25713995. PMCID: PMC4594535.
Short-Term Increases in Transient Receptor Potential Vanilloid-1 Mediate Stress-Induced Enhancement of Neuronal Excitation. Weitlauf, Carl; Ward, Nicholas J.; Lambert, Wendi S.; Sidorova, Tatiana N.; Ho, Karen W.; Sappington, Rebecca M.; Calkins, David J. Journal of Neuroscience. 2014. 34(46); 15369-15381. DOI: 10.1523/jneurosci.3424-14.2014. PMID: 25392504. PMCID: PMC4228139.
Transcellular degradation of axonal mitochondria. Davis, Chung-ha O.; Kim, Keun-Young; Bushong, Eric A.; Mills, Elizabeth A.; Boassa, Daniela; Shih, Tiffany; Kinebuchi, Mira; Phan, Sebastien; Zhou, Yi; Bihlmeyer, Nathan A.; Nguyen, Judy V.; Jin, Yunju; Ellisman, Mark H.; Marsh-Armstrong, Nicholas. Proceedings of the National Academy of Sciences of the United States of America. 2014. 111(26); 9633-9638. DOI: 10.1073/pnas.1404651111. PMID: 24979790. PMCID: PMC4084443.
Activation of the TRPV1 cation channel contributes to stress‐induced astrocyte migration. Ho, Karen W.; Lambert, Wendi S.; Calkins, David J. Glia. 2014. 62(9); 1435-1451. DOI: 10.1002/glia.22691. PMID: 24838827. PMCID: PMC4107153.
Absence of Transient Receptor Potential Vanilloid-1 Accelerates Stress-Induced Axonopathy in the Optic Projection. Ward, Nicholas J.; Ho, Karen W.; Lambert, Wendi S.; Weitlauf, Carl; Calkins, David J. Journal of Neuroscience. 2014. 34(9); 3161-3170. DOI: 10.1523/jneurosci.4089-13.2014. PMID: 24573275. PMCID: PMC3935081.
Differential Progression of Structural and Functional Alterations in Distinct Retinal Ganglion Cell Types in a Mouse Model of Glaucoma. Della Santina, Luca; Inman, Denise M.; Lupien, Caroline B.; Horner, Philip J.; Wong, Rachel O. L. Journal of Neuroscience. 2013. 33(44); 17444-17457. DOI: 10.1523/jneurosci.5461-12.2013. PMID: 24174678. PMCID: PMC3812509.
Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy. Dapper, Jason D.; Crish, Samuel D.; Pang, Iok-Hou; Calkins, David J. Neurobiology of Disease. 2013. 59(); 26-37. DOI: 10.1016/j.nbd.2013.07.001. PMID: 23859799. PMCID: PMC3775981.
α-Lipoic Acid Antioxidant Treatment Limits Glaucoma-Related Retinal Ganglion Cell Death and Dysfunction. Inman, Denise M.; Lambert, Wendi S.; Calkins, David J.; Horner, Philip J. PLOS ONE. 2013. 8(6); e65389. DOI: 10.1371/journal.pone.0065389. PMID: 23755225. PMCID: PMC3673940.
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Welsbie, Derek S.; Yang, Zhiyong; Ge, Yan; Mitchell, Katherine L.; Zhou, Xinrong; Martin, Scott E.; Berlinicke, Cynthia A.; Hackler, Laszlo; Fuller, John; Fu, Jie; Cao, Li-hui; Han, Bing; Auld, Douglas; Xue, Tian; Hirai, Syu-ichi; Germain, Lucie; Simard-Bisson, Caroline; Blouin, Richard; Nguyen, Judy V.; Davis, Chung-ha O.; Enke, Raymond A.; Boye, Sanford L.; Merbs, Shannath L.; Marsh-Armstrong, Nicholas; Hauswirth, William W.; DiAntonio, Aaron; Nickells, Robert W.; Inglese, James; Hanes, Justin; Yau, King-Wai; Quigley, Harry A.; Zack, Donald J. Proceedings of the National Academy of Sciences of the United States of America. 2013. 110(10); 4045-4050. DOI: 10.1073/pnas.1211284110. PMID: 23431148. PMCID: PMC3593842.
Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target. Crish, S.D.; Dapper, J.D.; MacNamee, S.E.; Balaram, P.; Sidorova, T.N.; Lambert, W.S.; Calkins, D.J. Neuroscience. 2012. 229(); 55-70. DOI: 10.1016/j.neuroscience.2012.10.069. PMID: 23159315. PMCID: PMC3534890.
Early Reduction of Microglia Activation by Irradiation in a Model of Chronic Glaucoma. Bosco, Alejandra; Crish, Samuel D.; Steele, Michael R.; Romero, Cesar O.; Inman, Denise M.; Horner, Philip J.; Calkins, David J.; Vetter, Monica L. PLOS ONE. 2012. 7(8); e43602. DOI: 10.1371/journal.pone.0043602. PMID: 22952717. PMCID: PMC3431380.
Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Calkins, David J. Progress in Retinal and Eye Research. 2012. 31(6); 702-719. DOI: 10.1016/j.preteyeres.2012.07.001. PMID: 22871543. PMCID: PMC3472111.
Early microglia activation in a mouse model of chronic glaucoma. Bosco, Alejandra; Steele, Michael R.; Vetter, Monica L. The Journal of Comparative Neurology. 2011. 519(4); 599-620. DOI: 10.1002/cne.22516. PMID: 21246546. PMCID: PMC4169989.
Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Lambert, Wendi S; Ruiz, Lupe; Crish, Samuel D; Wheeler, Larry A; Calkins, David J. Molecular Neurodegeneration. 2011. 6(1); 4. DOI: 10.1186/1750-1326-6-4. PMID: 21232114. PMCID: PMC3035592.
Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Nguyen, Judy V.; Soto, Ileana; Kim, Keun-Young; Bushong, Eric A.; Oglesby, Ericka; Valiente-Soriano, Francisco J.; Yang, Zhiyong; Davis, Chung-ha O.; Bedont, Joseph L.; Son, Janice L.; Wei, John O.; Buchman, Vladimir L.; Zack, Donald J.; Vidal-Sanz, Manuel; Ellisman, Mark H.; Marsh-Armstrong, Nicholas. Proceedings of the National Academy of Sciences of the United States of America. 2011. 108(3); 1176-1181. DOI: 10.1073/pnas.1013965108. PMID: 21199938. PMCID: PMC3024691.
Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms. Crish, S.D.; Calkins, D.J. Neuroscience. 2010. 176(); 1-11. DOI: 10.1016/j.neuroscience.2010.12.036. PMID: 21187126. PMCID: PMC3040267.
Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration. Baltan, Selva; Inman, Denise M.; Danilov, Camelia A.; Morrison, Richard S.; Calkins, David J.; Horner, Philip J. Journal of Neuroscience. 2010. 30(16); 5644-5652. DOI: 10.1523/jneurosci.5956-09.2010. PMID: 20410117. PMCID: PMC2884009.
Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Crish, Samuel D.; Sappington, Rebecca M.; Inman, Denise M.; Horner, Philip J.; Calkins, David J. Proceedings of the National Academy of Sciences of the United States of America. 2010. 107(11); 5196-5201. DOI: 10.1073/pnas.0913141107. PMID: 20194762. PMCID: PMC2841892.
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons. Uo, Takuma; Dworzak, Jenny; Kinoshita, Chizuru; Inman, Denise M.; Kinoshita, Yoshito; Horner, Philip J.; Morrison, Richard S. Experimental Neurology. 2009. 218(2); 274-285. DOI: 10.1016/j.expneurol.2009.05.010. PMID: 19445933. PMCID: PMC2733949.
Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand. Wax, Martin B.; Tezel, Gülgün; Yang, Junjie; Peng, Guanghua; Patil, Rajkumar V.; Agarwal, Neeraj; Sappington, Rebecca M.; Calkins, David J. Journal of Neuroscience. 2008. 28(46); 12085-12096. DOI: 10.1523/jneurosci.3200-08.2008. PMID: 19005073. PMCID: PMC2683273.
Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma. Buckingham, Brian P.; Inman, Denise M.; Lambert, Wendi; Oglesby, Ericka; Calkins, David J.; Steele, Michael R.; Vetter, Monica L.; Marsh-Armstrong, Nicholas; Horner, Philip J. Journal of Neuroscience. 2008. 28(11); 2735-2744. DOI: 10.1523/jneurosci.4443-07.2008. PMID: 18337403. PMCID: PMC6670674.
Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model. Soto, Ileana; Oglesby, Ericka; Buckingham, Brian P.; Son, Janice L.; Roberson, Elisha D. O.; Steele, Michael R.; Inman, Denise M.; Vetter, Monica L.; Horner, Philip J.; Marsh-Armstrong, Nicholas. Journal of Neuroscience. 2008. 28(2); 548-561. DOI: 10.1523/jneurosci.3714-07.2008. PMID: 18184797. PMCID: PMC6670511.
Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Inman, D. M.; Horner, P. J. Glia. 2007. 55(9); 942-953. DOI: 10.1002/glia.20516. PMID: 17457855.
Fate of endogenous stem/progenitor cells following spinal cord injury. Horky, Laura L.; Galimi, Francesco; Gage, Fred H.; Horner, Philip J. The Journal of Comparative Neurology. 2006. 498(4); 525-538. DOI: 10.1002/cne.21065. PMID: 16874803. PMCID: PMC2553041.