glaucoma research foundation logo in black
Search
Generic filters
Filter by Categories
Eye Health
Personal Stories
Facts & Stats
Lifestyle Tips
Eye Exams
Treatments
Q&A
Research Updates
News
Search
Generic filters
Filter by Categories
Eye Health
Personal Stories
Facts & Stats
Lifestyle Tips
Eye Exams
Treatments
Q&A
Research Updates
News

Catalyst for a Cure Researchers Discover Clue to How to Protect Neurons and Encourage Their Growth

The Catalyst for a Cure researchers are a team of four principal investigators and their laboratories working together to restore vision and cure glaucoma.

BACK TO BLOG HOME

researchers in lab looking at microscope
researchers in lab looking at microscope

Catalyst for a Cure Researchers Discover Clue to How to Protect Neurons and Encourage Their Growth

The Catalyst for a Cure researchers are a team of four principal investigators and their laboratories working together to restore vision and cure glaucoma.

Researchers in the Catalyst for a Cure (CFC) Vision Restoration team funded by Glaucoma Research Foundation reported in a study published December 14, 2020 in PNAS (The Proceedings of the National Academy of Sciences) that by inhibiting a particular family of enzymes, it may be possible to develop new therapies for treating neurodegenerative diseases including glaucoma and Alzheimer’s.

The CFC researchers summarized the importance of the findings as follows:

In glaucoma, retinal ganglion cells and their axons in the optic nerve do not all degenerate at a common rate. Thus, at any point in progression, some cells stressed by the disease remain functional, while others have lost their axons entirely. To preserve vision, different strategies are therefore needed to protect healthy ganglion cells, repair those in early stages, and regenerate those that have lost axons and connectivity with the visual brain.

A tacit assumption has been that therapies that protect the ganglion cell projection in glaucoma should also help them regenerate – that is, protect, repair and regenerate are all part of the same category of therapy. However, this is not the case. While inhibiting some pathways protects ganglion cells, the same strategy may prevent regeneration. This is so for a pair of kinases, for example, the dual leucine zipper kinase (or DLK) and the leucine zipper-bearing Kinase (or LZK).

Finally, however, there is hope to achieve both purposes with a single therapeutic intervention. The laboratory of Dr. Derek Welsbie, in collaboration with the Catalyst for a Cure team, discovered a novel strategy that can promote both neuroprotection and regeneration of ganglion cells and their axons.

This approach is based on the inhibition of a family of molecules called GCK-IV (germinal cell kinase four) using a single drug. Importantly, the CFC team now finds that the same strategy is also effective to potentiate the survival and growth of retinal ganglion cells produced from stem cells in a dish.

This new strategy will be beneficial in both preventing ganglion cell degeneration to preserve vision and in advancing cell replacement therapies in cases where the optic nerve has degenerated entirely.

Read the UC San Diego news release here…

 

Posted on December 22, 2020

image_print
back of mailing envelope. snail mail icon.

Print Subscription

(The printed edition of the Gleams newsletter is only available if you live in the United States or Canada)

Name(Required)
Address(Required)
This field is for validation purposes and should be left unchanged.

You can unsubscribe at any time. GRF will not share your personal information with any other organizations. Please see our Privacy Policy for further information.

folded paper airplane. email icon.

E-mail Subscription

Name
This field is for validation purposes and should be left unchanged.

You can unsubscribe at any time. GRF will not share your personal information with any other organizations. Please see our Privacy Policy for further information.